A previously healthy, white 12-year-old girl presented with diffuse body aches and poor perfusion. She developed severe respiratory failure and marked rhabdomyolysis and was mechanically ventilated. Although her CPK peaked at 500,000 IU/L, her renal function was mildly affected and her creatinine did not exceed the 0.8 mg/dL. The rhabdomyolysis was gradually resolved following aggressive fluid hydration. The patient did not require dialysis and made a complete recovery. Genetic studies revealed the diagnosis of McArdle disease.
Our study provides for the first time evidence for the implication of NKT-like cells in the pathogenesis of COP, as part of both localized and systemic cytotoxicity.
Preterm AGA infants with birth weights 9 0 0-1 4 0 0 g are studied in this controlled randomized multicenter trial. The infants are followed from 3 t o 8 weeks of age with a further assessment a t the age of 1 6 weeks. Only "healthy preterms" are included. Human milk is given throughout the study, and both treatment group and controls receive extra protein and iron t o ensure sufficient supply for increased red cell production. Milk protein (0.9 gllOO rnl human milk) and oral iron I18 mg Fe++lday increasing t o 36 mglday if serum iron falls below 1 6 pmolll) are given. EPO (Eprex, Cilag AG) is given s.c. thrice weekly; 1 0 0 IUIkgldose from week 3 t o week 7. Until now 2 4 children have been included (1 0 treated & 1 4 controlsl. Preliminary data show : BW of the groups are similar (1 2 9 4 g and 1 2 4 4 g). There
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