The enzyme-catalyzed hydrolysis of glucosidic bonds, a pivotal reaction in carbohydrate metabolism,1 is thought to involve a transient, point-charge-stabilized oxocarbonium ion 1 (Scheme I) whose subsequent processing results in overall retention or inversion of glucoside stereochemistry. Analogues of this glucosyl cation have long represented an attractive synthetic target for the design of potent glucosidase inhibitors.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.