The criterion validity of the Beck Depression Inventory-II (BDI-II; A. T. Beck, R. A. Steer, & G. K. Brown, 1996) was investigated by pairing blind BDI-II administrations with the major depressive episode portion of the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I; M. B. First, R. L. Spitzer, M. Gibbon, & J. B. W. Williams, 1997) in a sample of 137 students receiving treatment at a university counseling center. Student BDI-II scores correlated strongly (r ϭ .83) with their number of SCID-I depressed mood symptoms. A BDI-II cut score of 16 yielded a sensitivity rate of 84% and a false-positive rate of 18% in identifying depressed mood. Receiver operating characteristic analyses were used to produce cut scores for determining severity of depressed mood. In a second study, a sample of 46 student clients were administered the BDI-II twice, yielding test-retest reliability of .96.

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terminated prepolymer when this material was found to react with ethanol during the capping operation. This reaction caused a shift in elution volume of the material, confirming the presence of reactive end groups as opposed to unreacted polyol.The chromatogram of the prepolymer, shown as composite Peak C in Figure 4, was obtained by fractionation on the high permeability limit columns. The long tail in the high molecular weight region indicates that the prepolymer had an extremely broad molecular weight distribution. Although no suitable calibration of elution volume in terms of absolute molecular weight was obtained for this polyurethane, ratios of i V w / J T n and iVz/iRw could be estimated from a polystyrene calibration. By this means it was estimated nw/nn to be 15 and Rz/Rw to be 4.6 where ivn is the number average molecular weight, ,Vw is the weight average molecular weight and Rz is the "z" average molecular weight. ACKNOWLEDGEMENTThe authors acknowledge Hans W. Osterhoudt for his valuable guidance and the work of the Analytical Department of Armstrong Cork Company for its supplementary analyses of materials.

IN A REVIEW of the current concepts of metabolism of anaesthetic agents by Greene, it is conspicuous that many of these drugs depend on the integrity of liver function for their detoxifieation. 1 For this reason, multiple hepatic enzyme systems have been repeatedly studied with each agent as it is introduced into experimental and clinical practice.Conney and his co-workers 2-~ have shown that "pretreatment" of rats with phenobarbital shortened the sleeping time produced by thiopental, hexobarbital, and pentobarbital. Other anaesthetic drugs which have been studied include morphine, meperidine HC1, urethane, codeine, gluthetimide, nitrous oxide, methoxyflurane, and carbromal.By direct methods, a quantitative increase in the liver microsomal enzyme activity has been demonstrated to be the responsible accelerating factor of the drugs' disposition. 8,5,6 Conversely, a prolonged effect can be attained by the previous adminislzation of compounds that would have an inhibiting action on the same enzyme systems. 7This study was intended to determine whether similar stimulating and inhibiting mechanisms would int/uence the sleeping times of rats receiving more recently introduced anaesthetics such as gamma hydroxybutyrate, 2-orthochlorophenyl, 2-methylaminocydohexanone (ci-581), and diazepam. To correlate our findings with previous reports, thiopental, pentobarbital, and the centrally acting muscle relaxant zoxazolamine were also tested. MATEt~ALS AND METHODSNineteen groups of ten rats each were divided into three allotments. Male albino Sprague-Dawley rats four to six weeks old and weighing 50 to 60 gm were used for all the studies. Intraperitoneal injections were given in the lower half of the abdomen in a dose corresponding to each animal's weight. The onset and duration of sleep were timed by the disappearance and return of the "righting reflex" (ability to turn spontaneously to the "on quarters" position when placed on the back). Animals that failed to show signs of anaesthesia were eliminated from the study.The sleep-time periods in minutes were added and mean-limes and standard devia6ons calculated. Statistical analysis of the results was conducted by the Student t-test.

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