Sustainability, information systems (IS), and sustainable supply chain management (SSCM) are the main research areas of this study. In an era where environmental and social responsibility is becoming increasingly more important, SSCM is very significant for the survivability and competitiveness of organizations. Information systems may facilitate sustainable practices, as they support supply chain processes, decrease costs, and enable the control and monitoring of operations. The aim of this research is to explore the relationship between information systems and SSCM and explain under what circumstances they could lead to competitive advantage or increase internal business performance. To analyze the above, the methodology comprises a literature review enabling the understanding and conceptualization of the main research constructs and revealing the gaps of previous research. It also comprises qualitative research based on a single-case study allowing an in-depth examination of the subject of study. The findings reveal that the use of information systems, combined with strong interorganizational relationships and collaboration, can support SSCM practices. They can bring important business advantages, such as improved business performance and increased customer loyalty, but not necessarily competitive advantage. The results of this research show that SSCM is a promising field of study, with prospects for future research.