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The toxicity of an endrin formulation to spring chinook and coho salmon, rainbow trout, bluegill, mosquitofish, guppies, and the marine threespine stickleback was determined at 20 ø C.Coho salmon were the most sensitive, with a 96-hour TL,• of 0.27 parts per billion endrin; sticklebacks were the most tolerant. A volume effect was demonstrated; bluegills died at lower concentrations of endrin in aquaria with the smallest number of fish. Temperature had a marked influence on toxicity of endrin to bluegills, the toxicity increasing with rise of temperature. Tolerance of endrin by marine threespine sticklebacks was about the same in waters of different salinities. Developing eggs and early larvae of the stickleback are more tolerant than fully developed fish.