The Probe Of Extreme Multi-Messenger Astrophysics (POEMMA) is designed to accurately observe ultra-high-energy cosmic rays (UHECRs) and cosmic neutrinos from space with sensitivity over the full celestial sky. POEMMA will observe the air fluorescence produced by extensive air showers (EASs) from UHECRs and potentially UHE neutrinos above 20 EeV. Additionally, POEMMA has the ability to observe the Cherenkov signal from upward-moving EASs induced by Earth-interacting tau neutrinos above 20 PeV. The POEMMA spacecraft are designed to quickly re-orientate to follow up transient neutrino sources and obtain currently unparalleled neutrino flux sensitivity. Developed as a NASA Astrophysics Probe-class mission, POEMMA consists of two identical satellites flying in loose formation in 525 km altitude orbits. Each POEMMA instrument incorporates a wide field-of-view (45∘) Schmidt telescope with an optical collecting area of over 6 m2. The hybrid focal surface of each telescope includes a fast (1 μs) near-ultraviolet camera for EAS fluorescence observations and an ultrafast (10 ns) optical camera for Cherenkov EAS observations. In a 5-year mission, POEMMA will provide measurements that open new multi-messenger windows onto the most energetic events in the universe, enabling the study of new astrophysics and particle physics at these extreme energies.

We present a targeted search for blazar flux-correlated high-energy (ε ν ∼ > 1 TeV) neutrinos from six bright northern blazars, using the public database of northern-hemisphere neutrinos detected during "IC40" 40-string operations of the IceCube neutrino observatory (April 2008 to May 2009). Our six targeted blazars are subjects of long-term monitoring campaigns by the VERITAS TeV γ-ray observatory. We use the publicly-available VERITAS lightcurves to identify periods of excess and flaring emission. These predefined intervals serve as our "active temporal windows" in a search for an excess of neutrinos, relative to Poisson fluctuations of the near-isotropic atmospheric neutrino background which dominates at these energies. After defining the parameters of an optimized search, we confirm the expected Poisson behavior with Monte Carlo simulations prior to testing for excess neutrinos in the actual data. We make two searches: One for excess neutrinos associated with the bright flares of Mrk 421 that occurred during the IC40 run, and one for excess neutrinos associated with the brightest emission periods of five other blazars (Mrk 501, 1ES 0805+524, 1ES 1218+304, 3C66A, and W Comae), all significantly fainter than the Mrk 421 flares. We find no significant excess of neutrinos from the preselected blazar directions during the selected temporal windows. We derive 90%-confidence upper limits on the number of expected flux-associated neutrinos from each search. These limits are consistent with previous point-source searches and Fermi GeV flux-correlated searches. Our upper limits are sufficiently close to the physically-interesting regime that we anticipate future analyses using already-collected data will either constrain models or yield discovery of the first blazar-associated high-energy neutrinos.

The Extreme Universe Space Observatory Super Pressure Balloon 2 (EUSO-SPB2) is under development, and will prototype instrumentation for future satellite-based missions, including the Probe of Extreme Multi-Messenger Astrophysics (POEMMA). EUSO-SPB2 will consist of two telescopes. The first is a Cherenkov telescope (CT) being developed to identify and estimate the background sources for future below-the-limb very high energy (E>10 PeV) astrophysical neutrino observations, as well as above-the-limb cosmic ray induced signals (E>1 PeV). The second is a fluorescence telescope (FT) being developed for detection of Ultra High Energy Cosmic Rays (UHECRs). In preparation for the expected launch in 2023, extensive simulations tuned by preliminary laboratory measurements have been performed to understand the FT capabilities. The energy threshold has been estimated at 10 18.2 eV, and results in a maximum detection rate at 10 18.6 eV when taking into account the shape of the UHECR spectrum. In addition, onboard software has been developed based on the simulations as well as experience with previous EUSO missions. This includes a level 1 trigger to be run on the computationally limited flight hardware, as well as a deep learning based prioritization algorithm in order to accommodate the balloon's telemetry budget. These techniques could also be used later for future, space-based missions.

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Mini-EUSO is the first mission of the JEM-EUSO program on board the International Space Station. It was launched in 2019 and it is currently located in the Russian section (Zvezda module) of the station and viewing our planet from a nadir-facing UV-transparent window. The instrument is based on the concept of the original JEM-EUSO mission and consists of an optical system employing two Fresnel lenses and a focal surface composed of 36 Multi-Anode Photomultiplier tubes, 64 channels each, for a total of 2304 channels with single photon counting sensitivity and an overall field of view of 44° × 44°. Mini-EUSO can map the night-time Earth in the near UV range (predominantly between 290 nm and 430 nm), with a spatial resolution of about 6.3 km and different temporal resolutions of 2.5 µ, 320 µs and 41 ms. Mini-EUSO observations are extremely important to better assess the potential of a space-based detector in studying Ultra-High Energy Cosmic Rays (UHECRs) such as K-EUSO and POEMMA. In this contribution we focus the attention on UV measurements, the observation of clouds and of certain categories of events that Mini-EUSO triggers with the shortest temporal resolution. We place them in the context of UHECR observations from space, namely the estimation of exposure and sensitivity to Extensive Air Showers.