significant reduction in serum protein-bound iodine and an increase in triiodothyroxine resin uptake in 11 patients with types III and IV hyperlipoproteinemia. The drug was administered orally at dosages of 10, 15, and 20 mg. per kilogram per day each for a period of 4 weeks, respectively. There were 4 week pre-and posttreatment periods with placebo. The free thyroxine levels and 131 124 hour thyroidal uptake before and after MK-185 therapy did not show significant change. Although thyroid-binding globulin capacity was reduced, the change was not significant. It is proposed that the drug interferes with the binding of thyroxine by plasma proteins.
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