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The purpose of this study was to validate a semiautomatic method for quantitating the size of relative myocardial perfusion defects from single-photon emission computed tomographic (SPECT) images. We 09). The correlation between the two was .70. The tomographic relative reduced perfusion volume occupied 11.4 + 7.8% of the left ventricular volume compared with 16.9 ± 9.3% (p = .003) for the measure in vitro. Correlation between the SPECT and anatomic estimates of relative reduced perfusion volume was high (r = .88). We conclude that the size of a relative myocardial perfusion defect can be accurately quantitated by single-photon tomography. The techniques described may prove useful in the assessment in vivo of interventions directed at altering myocardial infarct size, in the determination of extent of ischemic myocardium, or in the diagnostic evaluation of patients with suspected coronary artery disease. Circulation 70, No. 6, 1048No. 6, -1056No. 6, , 1984 THE SEARCH FOR accurate noninvasive methods for determining the size of myocardial infarction has been the aim of many investigations.1"'°The use of therapeutic interventions designed to decrease infarct size has been an impetus for the development of measurements of size that might be applied clinically. Several

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