Context. In its first 4 years of observing the sky above 20 keV, INTEGRAL-ISGRI has detected 500 sources, around half of which are new or unknown at these energies. Follow-up observations at other wavelengths revealed that some of these sources feature unusually large column densities, long pulsations, and other interesting characteristics. Aims. We investigate where new and previously-known sources detected by ISGRI fit in the parameter space of high-energy objects, and we use the parameters to test correlations expected from theoretical predictions. For example, the influence of the local absorbing matter on periodic modulations is studied for Galactic High-Mass X-ray Binaries (HMXBs) with OB supergiant and Be companions. We examine the spatial distribution of different types of sources in the Milky Way using various projections of the Galactic plane, in order to highlight signatures of stellar evolution and to speculate on the origin of the group of sources whose classifications are still uncertain. Methods. Parameters that are available in the literature, such as positions, photoelectric absorption (N H ), spin and orbital periods, and distances or redshifts, were collected for all sources detected by ISGRI. These values and their references are provided online. Results. ISGRI has detected similar numbers of X-ray Binaries and Active Galactic Nuclei (AGN). The former group contains new members of the class of HMXBs with supergiant stellar companions. Usually, this type of object presents strong intrinsic absorption which leads to a peak emission in an energy range that ISGRI is ideally suited to detect. Thanks to these additional systems, we are able to show that HMXBs are generally segregated in plots of intrinsic N H versus the orbital period of the system and versus the spin period of the pulsar, based on whether the companion is a Be or an OB supergiant star. We also find a tentative but expected anticorrelation between N H and the orbital period, and a possible and unexpected correlation between the N H and the spin period. While only a handful of new Low-Mass X-ray Binaries (LMXBs) have been discovered, there are many sources that remain unclassified and they appear to follow a spatial distribution typical of Galactic sources (especially LMXBs) rather than extragalactic sources.

Key Points CMV is prevalent in pretreatment bone marrow from childhood ALL and not in acute myeloid leukemia. In utero infection with CMV is a risk factor for ALL (OR = 3.71, P = .0016) and is more pronounced in Hispanics (OR = 5.90, P = .006).

Aims. Active Galactic Nuclei are known to be variable throughout the electromagnetic spectrum. An energy domain poorly studied in this respect is the hard X-ray range above 20 keV. Methods. The first 9 months of the Swift/BAT all-sky survey are used to study the 14−195 keV variability of the 44 brightest AGN. The sources have been selected due to their detection significance of >10σ. We tested the variability using a maximum likelihood estimator and by analysing the structure function. Results. Probing different time scales, it appears that the absorbed AGN are more variable than the unabsorbed ones. The same applies for the comparison of Seyfert 2 and Seyfert 1 objects. As expected the blazars show stronger variability. 15% of the non-blazar AGN show variability of >20% compared to the average flux on time scales of 20 days, and 30% show at least 10% flux variation. All the non-blazar AGN which show strong variability are low-luminosity objects with L (14−195 keV) < 10 44 erg sConclusions. Concerning the variability pattern, there is a tendency of unabsorbed or type 1 galaxies being less variable than the absorbed or type 2 objects at hardest X-rays. A more solid anti-correlation is found between variability and luminosity, which has been previously observed in soft X-rays, in the UV, and in the optical domain.

Background Humans and viruses have co-evolved for millennia resulting in a complex host genetic architecture. Understanding the genetic mechanisms of immune response to viral infection provides insight into disease etiology and therapeutic opportunities. Methods We conducted a comprehensive study including genome-wide and transcriptome-wide association analyses to identify genetic loci associated with immunoglobulin G antibody response to 28 antigens for 16 viruses using serological data from 7924 European ancestry participants in the UK Biobank cohort. Results Signals in human leukocyte antigen (HLA) class II region dominated the landscape of viral antibody response, with 40 independent loci and 14 independent classical alleles, 7 of which exhibited pleiotropic effects across viral families. We identified specific amino acid (AA) residues that are associated with seroreactivity, the strongest associations presented in a range of AA positions within DRβ1 at positions 11, 13, 71, and 74 for Epstein-Barr virus (EBV), Varicella zoster virus (VZV), human herpesvirus 7, (HHV7), and Merkel cell polyomavirus (MCV). Genome-wide association analyses discovered 7 novel genetic loci outside the HLA associated with viral antibody response (P < 5.0 × 10−8), including FUT2 (19q13.33) for human polyomavirus BK (BKV), STING1 (5q31.2) for MCV, and CXCR5 (11q23.3) and TBKBP1 (17q21.32) for HHV7. Transcriptome-wide association analyses identified 114 genes associated with response to viral infection, 12 outside of the HLA region, including ECSCR: P = 5.0 × 10−15 (MCV), NTN5: P = 1.1 × 10−9 (BKV), and P2RY13: P = 1.1 × 10−8 EBV nuclear antigen. We also demonstrated pleiotropy between viral response genes and complex diseases, from autoimmune disorders to cancer to neurodegenerative and psychiatric conditions. Conclusions Our study confirms the importance of the HLA region in host response to viral infection and elucidates novel genetic determinants beyond the HLA that contribute to host-virus interaction.