OBJECTIVE To investigate compositional cartilage changes measured with 3T MRI-based T2 values over 48 months in overweight and obese individuals with different degrees of weight loss and to study whether weight loss slows knee cartilage degeneration and symptom worsening. DESIGN We studied participants from the Osteoarthritis Initiative with risk factors or radiographic evidence of mild to moderate knee OA with a baseline BMI ≥25kg/m2. We selected subjects who over 48 months lost a, moderate (BMI change, 5-10%, n=180) or large amount of weight (≥10%, n=78) and frequency-matched these to individuals with stable weight relative to their baseline BMI (<3%, n=258). T2 maps of the cartilage compartments of the right knee, grey-level co-occurrence matrix (GLCM) texture and laminar analyses were evaluated and associations with weight loss and clinical symptoms (WOMAC subscales for pain, stiffness and disability) were assessed using multivariable regression models adjusting for age, sex, baseline BMI and KL. RESULTS The amount of weight change was significantly associated with change in cartilage T2 of the medial tibia (β 0.9ms, 95%CI 0.4 to 1.1, P=0.001). An increase of T2 in the medial tibia was significantly associated with an increase in WOMAC pain (β 0.5ms, 95%CI 0.2 to 0.6, P=0.02) and disability (β 0.03ms, 95%CI 0.003 to 0.05, P=0.03. GLCM contrast and variance over all compartments showed significantly less progression in the >10% weight loss group compared to the stable weight group (both comparisons, P=0.04). CONCLUSIONS Weight loss over 48 months is associated with slowed knee cartilage degeneration and improved knee symptoms.
• We investigated the association of paraspinal muscle fat fraction based on chemical shift encoding-based water-fat MRI with isometric strength measurements in healthy subjects. • Erector spinae muscle PDFF correlated significantly with relative muscle strength. • PDFF measurements improved prediction of paraspinal muscle strength beyond CSA.
Purpose: To investigate change in knee cartilage composition over 96 months in overweight and obese participants with constant weight compared to those with weight loss (WL), and to assess how different WL regimens are associated with these changes. Methods: We studied right knees of 760 participants (age 62.6 ± 9.0y; 465 females) with a baseline body mass index (BMI) >25 kg/m2 from the Osteoarthritis Initiative with mild to moderate or with risk factors for knee osteoarthritis. Participants losing weight (>5% of baseline BMI over 72 months; N ¼ 380) were compared to controls with stable weight (SW, N ¼ 380). Participants losing weight were categorized based on WL method (diet and exercise, diet only, exercise only) and compared to those with stable weight. Magnetic resonance imaging (MRI) at 3T was performed at baseline, 48-and 96-months. The association of WL and WL method with change in cartilage composition, measured with T2 mapping, was analyzed using mixed random effects models. Results: Compared to SW, WL was associated with a significantly slower increase in global (averaged over all compartments) cartilage T2 (adjusted mean difference of change in T2 ms/year [95% CI] between the groups: 0.24 [0.20, 0.41] ms/year; P < 0.001) and global deep layer cartilage T2 0.35 [0.20, 0.42] ms/ year; P < 0.001), suggesting slower cartilage deterioration. Compared to the SW group, slower increases in global T2 were observed in the diet and diet and exercise groups, but not in the exercise only group (P ¼ 0.042, P ¼ 0.003 and P ¼ 0.85, respectively). Conclusion: Our results suggest that WL may slow knee cartilage degeneration over 96 months, and that these potential benefits may differ by method of WL.
Objective: To investigate whether T2 relaxation time measurements of cartilage repair tissue and structural changes of the knee joint are associated with subchondral bone architecture after spongiosaaugmented matrix-associated autologous chondrocyte implantation (MACI). Design: Both knees of 25 patients (25.5 ± 7.8y; 10 women) were examined preoperatively and 2.7 years after unilateral spongiosa-augmented MACI with 3T magnetic resonance (MR) imaging. Cartilage composition was assessed using T2 relaxation time measurements, subchondral trabecular bone microstructure was quantified using a 3D phase-cycled balanced steady state free-precision sequence. Structural knee joint changes were assessed using the modified Whole-Organ Magnetic Resonance Imaging Score (WORMS). The Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score was used for the postoperative description of the area that underwent MACI. Correlations were assessed using Spearman's rank correlation coefficients. Results: Hypertrophy of the cartilage repair tissue was found in 2 of 25 patients, both after a MACI procedure at the patella, 21 patients showed congruent filling. In subchondral bone of the cartilage repair compartment, apparent trabecular thickness was significantly higher in compartments with elevated cartilage T2 (n ¼ 17; 0.37 ± 0.05 mm) compared to those showing no difference in cartilage T2 compared to the same compartment in the contralateral knee (n ¼ 8; 0.27 ± 0.05 mm; P ¼ 0.042). Significant correlations were found between the overall progression of WORMS and the ipsilateral vs contralateral ratio of average trabecular thickness (r ¼ 0.48, P ¼ 0.031) and bone fraction (r ¼ 0.57, P ¼ 0.007). Conclusions: After spongiosa-augmented MACI, T2 values of cartilage repair tissue and structural knee joint changes correlated with the quality of the underlying trabecular bone.
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