335 Background: There has been a paradigm shift in the treatment of stage 1 pancreatic adenocarcinoma (PAC) from surgery first followed by adjuvant therapy (AT) to Neoadjuvant therapy (NAT) first followed by surgery and this is reflected in the current NCCN guidelines as well. Data comparing these two modalities are limited. AIM: To compare long time survival between surgery vs Surgery + AT and NAT + Surgery in a large National Cancer Database. Methods: We identified patients with surgically resected AJCC clinical stage 1, 1A, and 1B PAC between 2004-2014. Patients were stratified into 3 groups to assess outcomes. Exclusion criteria: those with incomplete survival and sequence of therapy data. Hazard ratios (HR) were calculated for evaluation of survival, as well as for 30-Day and 90-Day Mortality between the 3 groups. Results were adjusted for age and Deyo-Charlson comorbidity index. Results: A total of 9684 pts with Clincal stage 1, 1A, 1B PAC between 2004-2014 were identified. Of these 2266 pts underwent surgery alone; 6222 had surgery followed by AT; and 1196 pts had neoadjuvant therapy followed by surgery. There was a HR of 0.995 (95% CI 0.935-1.058 p = 0.864) and 0.984 (95% CI 0.924-1.048, p = 0.617) for 30- and 90-Day mortality comparing upfront surgery to NAT, respectively. With AT as the reference group for survival, there was a HR of 1.362 (95% CI 1.286-1.443, p < 0.001) for surgery only and HR of 0.929 (95% CI 0.859-1.004, p = 0.064) for NAT. Conclusions: 1. Surgery alone had worse overall survival. 2. There was no significant difference in overall survival when comparing AT and NAT 3. A prospective randomized trial evaluating the differences in survival is needed.
Objective: The purpose of this study was to examine race and ethnicity for overall survival (OS) and percent survival after 5- and 10-years for patients diagnosed with one of the gastrointestinal (GI) cancers.Method: We used national data for 12 types of GI cancers (esophagus, stomach, gallbladder, intrahepatic bile duct, extrahepatic bile duct, liver, pancreas, small intestine, colon, rectosigmoid, rectum, and anal) for the years 2004-2016. Results: A total of 2,249,213 patients diagnosed with one of the GI tract cancers with median age of 67 years were included in this study. There were 55% male, 77% non-Hispanic White (NHW), 12% were non-Hispanic Black (NHB), 6% were Hispanic, and the rest were classified as ‘Other’ race (4%). OS was higher for the Hispanics, followed by the ‘Other’, NHW and NHB (P <0.001). After adjusting for sex, income, insurance status, grade differentiation, age, and for Charlson-Dayo index, Hispanics and ‘Other’ race category had lower mortality compared to NHW (HR=0.93, 0.92-0.94, p <0.001; HR=0.92, 0.91-0.93, p <0.001), whereas NHB had higher risk compared to NHW (HR=1.09,1.08-1.09 p <0.001). Hispanics had lower mortality than NHW for 11 or 12 types (except esophagus), and ‘Other’ race category had lower risk for 10 of 12 types (except anal and small intestine). Five- and 10-year survival rates were higher for Hispanic patients (47%, 36%) followed by ‘Other’ (42%, 31%), NHW (40%, 28%), and for NHB (38%, 28%).Conclusion: Hispanics and the patients from ‘Other’ race category diagnosed with one of the GI cancers had longer survival probability and lower risk of mortality compared to NHW and NHB.
100 Background: Current guidelines recommend esophagectomy for submucosal T1b esophageal cancer. Data regarding efficacy of endoscopic resection (ER) of T1b esophageal cancer are limited. Our goal was to compare survival outcomes of ER as opposed to conventional surgical resection (SR) in a large cohort of patients with T1b cancers from a large national database. Methods: Data were obtained from the large national database maintained by the Commission on Cancer. Patients with T1b esophageal cancers with clinical stage 1A and 1B who underwent ER and SR between 2010 and 2014 were identified using the American Joint Committee on Cancer (AJCC Version 7). Patients undergoing ER and SR were identified. Patients who underwent neoadjuvant therapy or had incomplete survival data were excluded. The primary outcome was survival for age and Deyo-Charlson comorbidity index. We also evaluated 30-Day and 90-Day Mortality outcomes. Results: There were 1071 patients with T1b esophageal cancer with complete mortality data. After selecting and excluding patients above, 141 patients were identified who underwent EET and 286 who underwent esophagectomy. Average age was 71.5 years in the ER group and 64.5 years in the SR group (p < 0.001). In the group, 30-Day mortality after surgery was 1/134 (0.8%, 7 missing) compared to surgery with 30-Day mortality of 6/283 (2.1%, 3 missing) (P = 0.308). 90-Day mortality after surgery for the ER group was 3/134 (2.2%, 7 missing) compared with the surgery with 90-Day mortality of 11/281 (3.9%, 5 missing) (P = 0.377). Adjusted for age and Deyo-Charlson comorbidity index, there was a HR of 1.051 (95% CI 0.695-1.589, p = 0.815) for mortality associated with surgery compared with ER. Mean follow-up of 42.6 months for the ER group and 55.7 months for surgery group. Conclusions: Based on the data from a large national cancer data base ER seems to be comparable to SR in terms of short term (30 day and 90 day) mortality. Overall survival seems to be similar in both groups Prospectively done randomized studies comparing ER versus SR are desirable.
607 Background: The number of cases of cancers originating from the gastrointestinal (GI) tract and from other associated GI organs has increased 28% between the years 2004-2014. The incidence and overall survival for GI tract related cancers shows systematic racial disparity. Our goal was evaluate racial disparity for overall survival and mortality among patients with GI tract cancers. Methods: We used the national cancer database to evaluate data from 12 types of GI tract cancers (esophagus, stomach, gallbladder, intrahepatic bile duct, extrahepatic bile duct, liver, pancreas, small intestine, colon, rectosigmoid, rectum, and anal) between the years 2004-2014. The racial categories included non-Hispanic white (NHW), non-Hispanic black (NHB), Hispanic, and Other (All other races were combined into an ‘Other’ category). We used Kaplan-Meier estimator with log-rank test for comparing the survival probability among the four race categories. We also used Cox regression to find out the hazard ratio for mortality adjusting for the age, sex, and Charlson index. Results: The study population included a total of 2,044,565 patients diagnosed with one of the GI tract cancers. Of the total 55% were male, 72% NHW 12% NHB, 0.4% Hispanic, and the rest were classified as ‘other’ race (16%) which includes majority of white or black Hispanic and Asian (82%), The mean age at diagnosis of the patients was 66.8 ± 11.3 years. Overall survival was better for the Hispanic group, followed by the ‘Other’ group, NHW and NHB (P < 0.001). Adjusted for age, sex, and for Charlson index, the hazards ratio was 0.93 (95% CI, 0.90-096, p < 0.001) for Hispanic vs other, 1.15 (95% CI, 1.14-1.16, p < 0.001) for NHB vs other, 0.98 (95% CI, 0.97-0.98, p < 0.001) for NHW vs others. Mortality rate among Hispanic, NHW, NHB, and other was 46.4%, 59.4%, 59.6%, 56.7%. Conclusions: With a very large study population the survival for Hispanic patient population as well as the ‘Other’ (majority of patients were Asian) category had higher overall survival probability and low rate mortality compared to other race categories. Possible hypotheses include dietary preferences, underlying genetic profile and environmental factors. Further studies are needed to confirm the hypotheses.
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