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The “Coherent Data Set” is a novel synthetic data set that leverages structured data from Synthea™ to create a longitudinal, “coherent” patient-level electronic health record (EHR). Comprised of synthetic patients, the Coherent Data Set is publicly available, reproducible using Synthea™, and free of the privacy risks that arise from using real patient data. The Coherent Data Set provides complex and representative health records that can be leveraged by health IT professionals without the risks associated with de-identified patient data. It includes familial genomes that were created through a simulation of the genetic reproduction process; magnetic resonance imaging (MRI) DICOM files created with a voxel-based computational model; clinical notes in the style of traditional subjective, objective, assessment, and plan notes; and physiological data that leverage existing System Biology Markup Language (SBML) models to capture non-linear changes in patient health metrics. HL7 Fast Healthcare Interoperability Resources (FHIR®) links the data together. The models can generate clinically logical health data, but ensuring clinical validity remains a challenge without comparable data to substantiate results. We believe this data set is the first of its kind and a novel contribution to practical health interoperability efforts.

Trials for therapies after an upper limb amputation (ULA) require a focus on the real-world use of the upper limb prosthesis. In this paper, we extend a novel method for identifying upper extremity functional and nonfunctional use to a new patient population: upper limb amputees. We videotaped five amputees and 10 controls performing a series of minimally structured activities while wearing sensors on both wrists that measured linear acceleration and angular velocity. The video data was annotated to provide ground truth for annotating the sensor data. Two different analysis methods were used: one that used fixed-size data chunks to create features to train a Random Forest classifier and one that used variable-size data chunks. For the amputees, the fixed-size data chunk method yielded good results, with 82.7% median accuracy (range of 79.3–85.8) on the 10-fold cross-validation intra-subject test and 69.8% in the leave-one-out inter-subject test (range of 61.4–72.8). The variable-size data method did not improve classifier accuracy compared to the fixed-size method. Our method shows promise for inexpensive and objective quantification of functional upper extremity (UE) use in amputees and furthers the case for use of this method in assessing the impact of UE rehabilitative treatments.