Objective: To examine whether the polymorphisms of the IL6, TNFA and IL10 genes represent a risk marker for acute myocardial infarction (AMI) and to analyze their correlation with risk factors, age of occurrence and type of AMI. Method: Association study that included 310 unrelated Venezuelan individuals, grouped in 190 patients with AMI and 120 controls with or without cardiovascular risk factors. The IL6-174 G/C (rs1800795), TNFA -308 G/A (rs1800629), and IL10-1082 A/G (rs1800896), -819 C/T (rs1800871) and -592 C/A (rs1800872) polymorphisms were determined using the polymerase chain reaction technique with sequence-specific primers. Results: Comparison of genotypic and allelic frequencies, using adjusted logistic regression analysis for risk factors, showed a significantly
Examinar si los polimorfismos de los genes IL6, TNFA e IL10 representan un marcador de riesgo de infarto agudo de miocardio (IAM) y analizar su correlación con los factores de riesgo, la edad de ocurrencia y el tipo de IAM. Método: Estudio de asociación que incluyó 310 individuos venezolanos, no relacionados, agrupados en 190 pacientes con IAM y 120 controles con o sin factores de riesgo cardiovascular. Los polimorfismos IL6-174 G/C (rs1800795), TNFA-308 G/A (rs1800629) e IL10-1082 A/G (rs1800896), -819 C/T (rs1800871) y -592 C/A (rs1800872) se determinaron utilizando la técnica reacción en cadena de la polimerasa con iniciadores de secuencias específicas. Resultados: La comparación de frecuencias genotípicas y alélicas, mediante el análisis de regresión logística ajustado para los factores de riesgo, mostró una frecuencia significativamente incrementada de la combinación de genotipos G/G-A/A de la variante TNFA-308 G/A
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