Background Identifying, reporting, measuring, and tracking events provide an opportunity to study system issues, motivate learning, measure the frequency and severity of events, and manage high-risk ones which refer to a safety culture that is focused on valuing the input of working staff and improving the quality of care. Aim Enhance the implementation of the occurrence variance reporting (OVR) system at the Obstetrics and Gynecological Hospital in Port Said Governorate, Egypt. Design A quasi-experimental research design for one group (pre–posttest) and a mixed-methods approach was conducted in this study. Method This study was carried out at an Obstetrics and Gynecological Hospital in Port Said Governorate, Egypt. Study subjects included a convenient sample of 100 doctors and nurses. The study used three tools: OVR Knowledge, Attitude, and Practice (KAP) questionnaire, the OVR trend analysis clinical audit checklist, and barriers that hinder staff to report patient safety events through two open-ended questions. Results Significant improvements were detected in the OVR system post-program implementation than pre-program implementation phase. A statistically significant increase in nurses’ and doctors’ total knowledge score from 0.74 to 3.39 and a statistically significant decrease in nurses’ and doctors’ total negative attitude score from 3.87 to 3.27. Also, a statistically significant increase in total practice score from 2.35 to 2.45. Conclusion There were significant improvements in the hospital OVR system postprogram implementation than preprogram implementation. Relevance to clinical practice To maintain performance and make sure that the original result is not lost, the health care facilities should emphasize the ongoing monthly and quarterly monitoring and analysis of data. Meetings, lectures, and training sessions are used for ongoing education.

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