Highlights
HDACs are dysregulated in various malignancies and in some inflammatory lung diseases.
HDAC inhibitors are emerging as a successful epigenetic therapy by exploiting pathophysiology of tumor microenvironment.
HDAC inhibitors can activate multiple antitumor pathway which results in the destruction of transformed cells.
Nanocarrier-based HDACi delivery is a huge step forward in improving the targeted delivery of HDAC inhibitors.
The Vehicle Routing Problem (VRP) is a NP-hard and Combinatorial optimization problem. Combinatorial optimization problem can be viewed as searching for best element in a set of discrete items, which can be solved using search algorithm or meta heuristic. In this work, VRP is solved using population based search algorithm, Particle Swarm Optimization (PSO) with crossover and mutation operators. In this paper, the PSO for VRP is considered from two aspects: the hybrid PSO algorithm and particle encoding method. The technical details required for this application are discussed. The computational result shows that the results of hybrid PSO for VRP are competitive.
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