Background: Prescription writing is an essential and a basic skill to be acquired by medical students during their training. Specific training and supervision in writing a rational prescription should be emphasized during undergraduate teaching to minimize prescription errors. Aims and Objectives: The prime objective of this study was to evaluate the ability of the second-year MBBS students to write a prescription and to assess the effectiveness of hands on training on appropriate prescription writing. Materials and Methods: A cross-sectional, observational study was conducted among 117 second-year MBBS students. Students were asked to write prescriptions for three case scenarios. An educational interventional session and hands on training was conducted. Post session the students were asked to write prescriptions for three different case scenarios. All the prescriptions were analyzed and feedback was given to the students. Results: 350 prescriptions each were collected pre-and post-educational interventional sessions from the students. The completeness of the prescriptions were analyzed on the basis of the prescriber and drug-related components. A widespread lacunae was observed in the prescription writing skills of the medical students, which improved significantly (P < 0.05) after the educational interventional sessions and hands on training. Conclusion: This study shows that hands on training has improved the prescription writing skills of the medical students. This type of training should be included as a part of pharmacology practical curriculum.
Background: Alzheimer's disease (AD) is a progressive neurodegenerative brain disorder, and it is the main cause of dementia in the elderly. At present, no proper cure is available to stop the progression of AD. The neuronal damage in AD is due to the deposition of β-amyloid peptide and tau protein within the brain. Curcumin a curry spice has several beneficial activities such as antioxidant, antimicrobial, anti-inflammatory, and chemotherapeutic properties. Aims and Objectives: The main objective was to perform molecular docking of curcumin and its derivatives with BACE1 to determine its binding efficacy and the absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties of the selected curcumin derivatives. Materials and Methods: Three-dimensional structure of the BACE1 was retrieved from RCSB database in protein data bank format. Total 200 ligand derivatives of curcumin were generated using the software advanced chemistry development/ChemSketch. The rapid virtual screening of the compounds was performed using the docking tool iGEMDOCK version 2.0. The ligands with low binding energy were selected and were analyzed for the drug-relevant properties. The final docking of the ligands was performed using the software AutoDock 4.0, based on the drug-like properties and the binding affinity. Results: Among the four ligands, based on the drug-likeness, the ligand (6Z)-1-(4-hydroxy-3-methoxy-2-nitrophenyl)-7-(4-hydroxy-3-methoxyohenyl) hepta-1,6-diene-3, 5-dione was the best. It had excellent binding energy with good ADMET properties. Conclusion: In this study, using the molecular docking method, a new compound has been identified to inhibit BACE1. This compound can be an effective drug candidate for controlling AD.
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