Non-invasive mucosal immune response plays an important role in controlling various infections through mucosal route. Therefore, the appropriate induction of effective immune response should be elicited after immunization. Currently, a lot of strategies have been investigated to enhance the mucosal immunity including microparticles, liposomes, virosomes, cochleates and aracheosomes. These carriers due to tunable and unique physicochemical properties offer the possibility for better antigen presentation by appropriate cells, being more effective to induce a comparable immune response. The objective of this review is to give an overview of novel strategies for the delivery of vaccines through the mucosal route.
Introduction:
Anti-angiogenic therapy can produce transient regression in tumor in case of Glioblastoma (GBM); however, no prolongation of patient survival rate had so far been achieved.
Methodology:
To address this problem, an effort was made to design and characterize a temozolomide loaded nanosystem for targeting the tumor vasculature in the brain using polymeric nanoparticles. It included the formation of Temozolomide (TMZ) loaded Solid-Lipid Nanoparticles (SLNs) and their conjugation with polysorbate-80 (P-80) which enhanced the penetration of drug to blood-brain barrier resulting in the enhancement of pro-apoptotic activity.
Results:
Conjugating nanoparticles with a tumor-penetrating polymer (P-80) further enhanced the therapeutic efficacy of the drug.
Conclusion:
The animal studies indicated the enhanced potential of the developed system in the effective treatment of glioblastoma.
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