No abstract

No abstract

Abstract:: In December 2019, a novel COVID-19 caused by SARS-CoV-2 has emerged as a global emergency. In a few months, the pathogen has infected millions of people in the world. Primarily SARS-CoV-2 infects the pulmonary system which ultimately leads to ARDS and lung failure. The majority of patients develop milder symptoms but the infection turns severe in a huge number of people which ultimately results in enhanced mortality in COVID-19 patients. Co-morbid conditions primarily cardiovascular complications and diabetes have been reported to show a strong correlation with COVID-19 severity. Further, the onset of myocardial injury secondary to pulmonary damage has been observed in critically ill patients who have never reported heart-related ailments before. Due to drastic health risks associated with virus infection, the unprecedented disruption in normal business throughout the world has caused an economic misery. Apparently, newer treatments are urgently needed to combat the virus particularly to reduce the severity burden. Therefore, understanding the cross-talk between lung and heart during COVID-19 might give us better clarity for early-diagnosis followed by appropriate treatment in patients with the likelihood of developing severe symptoms. Accordingly, the present review highlights the potential mechanisms that may explain the cross-talk between lung and heart so that effective treatment/management strategies can be evolved swiftly in this direction.

No abstract

: A novel coronavirus SARS-CoV-2 which initially originated in China has outstretched to all nations and turned out to be an intense global concern for both the governments and the public. In addition to the health concerns, COVID-19 pandemic has caused tremendous impact on economic and political conditions of every nation. Ever since the start of pandemic the physicians were constrained to rely on the management strategies due to lack of clear understanding of the disease pathogenesis caused by SARS-CoV-2 infection. Scientists are working tirelessly to gather maximum information about the deadly virus and come up with various strategies which can be used against COVID-19 infection in terms of therapeutics and vaccine development. It is quite evident that virus infection leads to acute respiratory distress syndrome (ARDS) and most of the deaths occur due to respiratory failure. As the virus spread through respiratory droplets, the strenuous exercise of preventive measures and large scale diagnosis has been in practice across the globe to prevent the transmission. This review amalgamates the various updates and acts as an umbrella to provide insights on SARS-CoV-2 mediated ARDS pathogenesis, impact of co-morbidities, diagnostics, current progress in vaccine development, and promising therapeutics and immuno-modulatory strategies highlighting various concerns and gaps that need to be addressed to fight current and future pandemics effectively.