Introduction and Aim: Diabetes mellitus is one of the commonest metabolic causes associated with hypomagnesaemia. Magnesium is said to be one of the chief neuroprotective and vasodilatory mineral of the body. The main aim of this study was to establish the potential correlation between the serum magnesium levels and the auditory acuity in type II Diabetes mellitus patients. Materials and Methods: It is a cross-sectional study done at Sree balaji medical college & hospital, Chrome pet, Chennai. In this study we evaluated a total of 200 type II DM cases consisting of 100 cases with poor glycaemic control, and 100 cases under glycaemic control, all are recently diagnosed cases of type II Diabetes mellitus, in the age groups of 40-55 years who had come to the hospital for their regular annual master check-ups. Their serum magnesium levels were measured using the xylidyl blue dye binding method and pure tone audiometry was also done. Results: Results showed that of the 100 poorly controlled type II DM subjects(i.e. HbA1c >/= 7),65 patients with hypomagnesaemia had sensory neural type of hearing loss & of the 100 type II DM subjects with controlled HbA1c levels(i.e. HbA1c<7), 8 out of the 10 subjects with hypomagnesaemia again had, sensory neural type of hearing loss. Conclusion: The results of this cross-sectional study proved that hypomagnesaemia results in the impairment of hearing, amidst the type II diabetic population, especially the poorly controlled diabetics are more vulnerable to develop hypomagnesaemia and its associated deafness. Thus periodic assessment of auditory status and serum magnesium levels is also required in all type II DM cases, as an early measure to prevent diabetes and hypo magnesia induced deafness.
The HbA1c levels, in general reflects the diabetic patients Glycaemic control status over the previous 3 months. HbA 1C concentrations may be increased by Anaemia due to iron deficiency, independent of glycaemia in diabetic patients. Henceforth this study serves to find if there is a positive correlation between the iron deficiency anaemia status & the HbA1c levels amidst the diabetic population. Materials and Methods: Cases-100 iron-deficiency anaemia patients with diabetes having controlled plasma glucose levels, Controls -100 non-anaemic diabetic individuals. The study was done in the premises of Sree Balaji Medical College & Hospital. HbA 1c levels was measured by ion exchange chromatography, ferritin by particle enhanced turbidometric immunoassay method, fasting plasma glucose by GOD -POD method.Results: We found that HbA1c was elevated (7.3±0.9) in iron-deficient diabetic individuals compared to normal level (5.4±0.6) in controls. Conclusion:The study showed that there was a positive correlation between the iron deficiency anaemia status and increased HbA 1c levels in the controlled diabetic population. Hence forth, the clinical significance of evaluating the iron deficiency anaemia status in diabetic patients has been proved to be significant in planning their further course of prompt diabetic management.
Introduction and Aim:Diabetes mellitus, especially type II DM is one among the most prevalent metabolic diseases in the global scale. One of the commonest complications of diabetes mellitus is vestibulopathy affecting the inner ear. Malondialdehyde (MDA) obtained from lipid peroxidation of poly unsaturated fatty acids (PUFA) is an important compound that generally serves as one of the key markers for oxidative stress. The aim of the study is to prove the significance of MDA in Vestibulopathy in Type-2 i.e.,non-insulin dependent diabetes mellitus. Methodology: A cross-sectional study of 100 diabetic patients of age group between 35 years and 50 years were tested for vestibular function by electronystagmography(Commonly used test to determine and evaluate vestibular system). Based on the biothermal caloric stimulation the Clausen butterfly chart was generated and thus the code is ascertained. Serum levels of Malon-di-aldehyde were assayed by TBARS method (Thiobarbituric acid Reactive substances). Results: The study proved, that there was a 4 times increased risk of developing vestibulopathy with increasing duration of diabetes. It also proved that there was an increased risk of developing vestibulopathy in diabetic patients, having MDA > 2?mol/L. Conclusion: Thereby the study confirmed the clinical significance of periodic screening of MDA levels, in diabetic patients, particularly those with uncontrolled/poor glycemic control & with longer duration of diabetes. Estimation of their serum MDAlevels and vestibular function by the electronystagmography test, is advised in order to prevent the occurrence of diabetic vestibulopathy at the earliest and also to prevent the worsening of any such, other complications associated with the disease.
Overweight (i.e. BMI of 25- 29.9) and Obesity (BMI ?30) continues to be one of the neglected global health problems. Leptin is one of the chief adipokines in the body that is basically involved in maintaining a balanced appetite in association with the various other adipokines like the adiponectin, ghrelin etc., Pranayama is the simplest and the ancient, dateless, venerable, non- pharmacological intervention that could be potentially used to maintain a healthy life. To determine how the regular practice of pranayama could significantly alter the deranged serum leptin levels in the obese. The correlative study was carried out in Sree Balaji Medical College & Hospital. The subjects included were 60 obese student volunteers of 17-19 years with no other known complications. We measured their serum leptin levels using ELISA method in the central laboratory, both before and after the pranayama training for 6 months. After 6 months of regular pranayama practice, there was a significant decrease in both their serum leptin levels and their BMI as well. Thus, it was concluded that we can potentially turn off our fat switch by beneficially reducing the serum leptin levels and enhancing the leptin receptor sensitivity in the obese with the regular practice of pranayama.
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