A new hydrogenation catalyst based on a manganese complex of a chiral P,N,N ligand has been found to be especially active for the hydrogenation of esters down to 0.1 mol % catalyst loading, and gives up to 97 % ee in the hydrogenation of pro-chiral deactivated ketones at 30-50 °C.
A new hydrogenation catalyst based on a manganese complex of a chiral P,N,N ligand has been found to be especially active for the hydrogenation of esters down to 0.1 mol% catalyst loading, and gives up to 97% e.e. in the hydrogenation of pro-chiral deactivated ketones at 30-50 o C.
A highly enantioselective synthesis of (S)‐flurbiprofen methyl ester in two steps from commercially available 4‐bromo‐2‐fluoro‐1,1′‐biphenyl is shown. [PdCl2((S)‐xylyl‐phanephos)] catalyst is used to accomplish both Grignard cross‐coupling and the highly enantioselective intermolecular methoxycarbonylation reaction.
As part of a programme aimed at exploiting lignin as a chemical feedstock for less oxygenated fine chemicals, several catalytic C-C bond forming reactions utilising guaiacol imidazole sulfonate are demonstrated. These include the cross-coupling of a Grignard, a non-toxic cyanide source, a benzoxazole, and nitromethane. A modified Meyers reaction is used to accomplish a second constructive deoxygenation on a benzoxazole functionalised anisole.
The challenging reaction of unactivated ortho-substituted aromatic ethers with Grignard reagents has been found to be most effectively catalysed using nickel complexes of less sterically hindered ligands.
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