well put young people at an unacceptable risk. A young person most likely needs higher absolute values to qualify for safe resection; in other words, a 25-yr-old patient with 20% ppo function for FEV1 has much more unhealthy lungs than a 70-yr-old patient with a ppo value of 30%, although in absolute values they both have 0.9 L.The current use of percent of predicted values has been shown to work well and, generally speaking, guidelines should suggest cut-off values which err on the side of safety. The trend to include more patients with marginal cardio-pulmonary functional reserves for resection will continue [4], but must be based on evidence.
Background:There is very limited data on the experience and outcome of multidrug-resistant tuberculosis (MDR-TB) patients treated privately out of the DOTS plus program. Goal of this study is to provide characteristics and treatment outcomes of a prospective cohort of MDR-TB patients managed at a private tertiary referral institute.Materials and Methods:A prospective analysis of a cohort of MDR-TB patients treated in a tertiary private hospital, with the back-up of a Level 2 mycobacterial laboratory, which has recently received recognition by the Revised National Tuberculosis Control Program (RNTCP) for second-line drug susceptibility (DST). All patients received an individualized MDR regimen on an ambulatory basis.Results:Our 68% success rates are respectable and show that given the right laboratory backing, MDR-TB can be managed successfully in selected private practice settings.
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