SUMMARY Among the survivors of Ebola virus disease (EVD), complications that include uveitis can develop during convalescence, although the incidence and pathogenesis of EVD-associated uveitis are unknown. We describe a patient who recovered from EVD and was subsequently found to have severe unilateral uveitis during convalescence. Viable Zaire ebolavirus (EBOV) was detected in aqueous humor 14 weeks after the onset of EVD and 9 weeks after the clearance of viremia.

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Purpose To analyze whether an association exists between keratometric and pachymetric changes in the cornea, and whether it can be used to create pachymetric cutoff criteria secondary to keratometric criteria. Methods In this cross-sectional study, 1000 candidates presenting to the refractive surgery services of a tertiary care hospital underwent bilateral Orbscan IIz (Bausch and Lomb) assessment along with other ophthalmic evaluation.Results Stepwise regression analysis-based models showed that simulated keratometry (simK) astigmatism was significantly predicted by the minimum corneal thickness (MCT) and difference between central and MCT (dCT), mean SimK by the MCT and dCT, and maximum keratometry in the central 10-mm zone by the MCT and dCT (Po0.001). The mean MCT values were 542.5±39.6, 539.9±39.2, 524.2±49.5, and 449.3±73.7 lm for flatter normal (o44 D), steeper normal (Z44 D), keratoconus suspect and keratoconic eyes, respectively (Po0.001). The mean differences between central corneal thickness and MCT (dCT) were 12.2 ± 7.1 lm, 12.4 ± 7.4 lm, 14.4 ± 8.9 lm and 23.2 ± 10.1 lm for the flatter normal, steeper normal, keratoconus suspect, and keratoconic eyes, respectively (Po0.001). Mean and 2SD cutoff were used to suggest that a cornea having MCTo461 lm or dCT427 lm has only a 2.5% chance of being normal and not a keratoconus suspect or worse. Conclusion Pachymetric diagnostic cutoffs can be used as adjuncts to the existing topographic criteria to screen keratoconus suspect and keratoconic eyes.

PurposeThe purpose of this study is to report a case of bilateral acute retinal necrosis in a patient with multiple sclerosis treated with natalizumab.MethodsThis study is a case report and literature review.ResultsA 34-year-old Caucasian female with multiple sclerosis presented with 1 week of blurry vision in both eyes during treatment with natalizumab. Clinical examination revealed bilateral acute retinal necrosis. The patient was treated with systemic intravenous acyclovir and intravitreal injections foscarnet and ganciclovir. Natalizumab therapy was also discontinued.ConclusionsNatalizumab is a potent immunosuppressive agent used in relapsing remitting multiple sclerosis and Crohn’s disease. The use of this medication is commonly associated with opportunistic infections in the CNS. In rare cases, ocular opportunistic infections may occur and can lead to significant visual impairment and blindness. Neurologists and ophthalmologists should be aware of this potential complication.