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In current scenario cloud computing is most widely increasing platform for task execution. Lot of research is going on to cut down the cost and execution time. In this paper, we propose an efficient algorithm to have an effective and fast execution of task assigned by the user. We proposed an effective communication framework between broker and virtual machine for assigning the task and fetching the results in optimum time and cost using Broker Virtual Machine Communication Framework (BVCF). We implement it over cloudsim under VM scheduling policies by modification based on Virtual Machine Cost. Scheduling over Virtual Machine as well as over Cloudlets and Retransmission of Cloudlets are the basic building blocks of the proposed work on which the whole architecture is dependent. Execution of cloudlets is being analyzed over Round Robin and FCFS scheduling policy.

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Clinical limitations and drug-resistance are the basis of the search for new antifungal therapeutics against biofilm forming pathogen Aspergillus fumigatus. Cis-9-hexadecenal is a natural compound present in various plants extracts, but its antifungal activity against A. fumigatus is still unexplored. The aim of present study was to evaluate the antifungal efficacy of cis-9-hexadecenal on A. fumigatus, specifically its biofilm and to assess its cytotoxicity. Broth micro-dilution method revealed that cis-9hexadecenal inhibited 90% of planktonic growth of A. fumigatus at 0.078 mg/ml. In-vitro combinatorial effect between drug amphotericin B and cis-9-hexadecenal was studied by checkerboard assay. Cis-9-hexadecenal, in combination to amphotericin-B had additive effect and showed enhanced drug efficacy against A. fumigatus. The effect of cis-9-hexadecenal on pre-formed biofilm was analyzed through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and scanning electron microscopy. In MTT assay, minimum biofilm-eradicating concentration-80 of cis-9-hexadecenal was 0.156 mg/ml. Scanning electron micrograph showed absence of extracellular matrix and tangled hyphae in cis-9-hexadecenal treated biofilm whereas these structures were present in both untreated and amphotericin-B treated biofilm. Drug-likeness was predicted through in-silico ADMET studies. The study envisaged that cis-9-hexadecenal followed Lipinski's rule but had a higher Log P value indicating that it's not hydrophilic. The compound can be modified to enhance the absorption and permeation. Cell cytotoxicity study exhibited that cis-9-hexadecenal was not toxic to normal human lung epithelial cell line L-132 upto 0.62 mg/ml. The study concluded that cis-9-hexadecenal might be explored further as a potential therapeutic molecule for A. fumigatus associated diseases.

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Due to the increasing complexity of web systems, security testing has become indispensable and critical activity of web application development life cycle. Security testing aims to maintain the confidentiality of the data, to check against any information leakage and to maintain the functionality as intended. It checks whether the security requirements are fulfilled by the web applications when they are subjected to malicious input data. Due to the rising explosion in the security vulnerabilities, there occurs a need to understand its unique challenges and issues which will eventually serve as a useful input for the security testing tool developers and test managers for their relative projects.