Objective: To study the anti-inflammatory activity of Escitalopram in newly diagnosed patients of depression. Materials and Methods: 100 Newly diagnosed patients of Depression as per ICD 10 (International classification of diseases) DCR (Diagnostic criteria for research) were selected for study after applying strict inclusion and exclusion criteria. Baseline Hamilton depression rating scale (HAMD) and baseline C reactive protein (CRP) was assessed and antidepressant treatment was started. After 8 weeks, again HAMD and CRP were assessed. Results: Mean of Baseline CRP was higher in patients in those who have no response after antidepressant treatment and it was significant. The relationship between baseline HAMD and baseline CRP was found to be significantly positively correlated. Mean HAMD was significantly reduced after 8 weeks of antidepressant treatment. Mean CRP was significantly reduced after 8 weeks of antidepressant treatment. The relationship between baseline CRP and reduction in HAM D (in baseline and after 8 weeks of treatment) found to be negatively correlated and it was significant. Conclusion: Escitalopram reduced C reactive protein in depressed patient and result was significant.
Background: Most common endocrine disorders seen globally are Thyroid disorders which pose a high burden on the health care sector globally including in India. Assessing these disorders definitively is a challenging condition for treating physicians as no single definitive test exists for confirmatory diagnosis of thyroid disorders. However, various clinical, FNAC (Fine needle aspiration cytology), and histopathologic tests can be done to diagnose these disorders. Histopathology remains the gold standard for confirmatory diagnosis of thyroid nodules. Aims: The present retrospective clinical study was conducted to assess the incidence and prevalence of thyroid disorders along with the indications of Thyroid surgeries in Indian subjects. Materials and Methods: In 50 subjects with thyroid nodules who underwent thyroidectomy, clinical data were retrospectively collected and assessed concerning clinical and histopathologic parameters of the thyroid nodule. The collected data were assessed to form results and were expressed as mean, number, and percentage. Results: Most common finding was movement with deglutition seen in 98% (n=49) subjects followed by laryngeal crepitus in 84% (n=42) subjects, mobility in 78% (n=39) subjects, tenderness in 20% (n=10) subjects, and pressure effect and neck nodes in 2% (n=1) subject each.
This study was conducted in a tertiary hospital's psychiatry unit. Legal edible cannabis (bhang) users for more than a year who attended the OPD and IPD during the study period and met the inclusion criteria (age 18 to 60, no history of physical or psychiatric illness) were included in the investigation with their informed consent. 171 patients were recruited after being assured of the study's confidentiality. Special tests evaluated cannabis dependence and psychiatric conditions. (1) CUDIT-R and (2) DSM-5 updated psychiatric morbidity criteria. Population demographics. Patients with CUDs ranged in age from 18 to 60. The majority were age 21 to 30 (49.7%), followed by 31 to 40 (29.8%), 41 to 50 (12.9%), 20 (5.8%), and 51 to 60. (1.8 percent). Male (93.1%) and female patients were roughly evenly split (7.0 percent). 103 of 171 study patients were married (60.2%), compared to 66 unmarried patients (38.6%) who used bhang more often. 1,2% were divorced. The study considered patients' education levels. Middle schoolers had the highest percentage (22.2%), followed by illiterates and graduates (17.5%), high school (12.9%), and postgraduates (0.6 percent). Lower middle class (40.9%) had the most participants, and upper class had the fewest (2.3 percent).
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