A detailed study was carried out on six biochemical parameters and four yield attributes using multiple regression analysis to investigate their relationship in the mulberry silkworm,Bombyx mori. The study generated new information on the importance of digestive amylase activity for the survival of the silkworm and revealed the inability of other enzymes to affect this relationship. Data also substantiate the observations made earlier on the genetic variability of amylase in the mulberry silkworm. Analyses extend the positive role of alkaline phosphatase and invertase in the expression of the other yield traits studied and indicate the definite possibility of using biochemical markers for silkworm breeding.
Blood protein markers have been studied for the clinical management of cancer. Due to the large number of the proteins existing in blood, it is often necessary to pre‐select potential protein markers before experimental studies. However, to date there is a lack of automated method for in‐silico selection of cancer blood proteins that integrates the information from both genetic and proteomic studies in a cancer‐specific manner. In this work, we synthesized both genomic and proteomic information from several open access databases and established a bioinformatic pipeline for in‐silico selection of blood plasma proteins overexpressed in specific type of cancer. We demonstrated the workflow of this pipeline with an example of breast cancer, while the methodology was applicable for other cancer types. With this pipeline we obtained 10 candidate biomarkers for breast cancer. The proposed pipeline provides a useful and convenient tool for in‐silico selection of candidate blood protein biomarkers for a variety of cancer research.
BACKGROUND Hoffa fractures are intra-articular femoral condyle fractures in the coronal plane. These are very uncommon injuries. The purpose of this study was radiologic and functional outcome assessment of surgically managed Hoffa fractures with headless compression screws. METHODS We prospectively studied 11 patients with isolated Hoffa fractures who were treated with open reduction and internal fixation using two or more headless compression screws. Antiglide plate was used only in one case. We used the midline parapatellar approach for all cases. All patients had gone through aggressive physiotherapy after the operation. All patients were evaluated radiologically and functionally on a regular interval. The functional outcome was recorded in terms of Lysholm score, Knee society score (KSS), Range of motion (ROM) and VAS score. RESULTS All fractures united radiologically with an average time of 3.3 months with no evidence of subsequent fixation failure. The mean Lysholm score and KSS at final follow-up were 88.6±7.1 and 86±7.6 respectively. The mean knee range of motion was from 0˚ to 120.5˚ ± 9.3˚. At the final follow-up, the mean VAS score dropped significantly to 0.63±0.8. CONCLUSIONS Operative management of Hoffa fractures with at least two headless compression screws can yield satisfactory functional and radiologic outcomes. Stable fixation and timely physiotherapy are the keys to success.
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