Introduction: Ketogenic diet has been evaluated for wide variety of conditions, although it was initially used for treatment of epilepsy. As alternative dietary pattern it can represent means of better quality of life, improved ability to work and can prevent against cognitive decline, different dementias and more serious forms of neurodegenerative diseases. Methods: This is a systematic review of available literature. Results: As energy substrates and as signaling agents, ketones are potentially usable in mitochondriopathies that come with aging and neurodegenerative diseases, or are a consequence of stroke, trauma. It has antioxidative, antiinflammatory and antiseizure properties, improves bioenergetics of the brain, neuronal plasticity and has epigenetic function. Discussion: Expansion of current nutritional knowledge might be a paradigmatic shift in understanding what is "healthy diet" in general or in terms of segments of population.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.