α‐Hydroxy‐α‐methyl ketones react with ammonia and aromatic aldehydes in the presence of calcium chloride and ammonium chloride to yield 2‐aryl‐3‐oxazolines.
Substituted 3-oxazolines react with m-chloroperoxybenzoic acid to give the corresponding These heterocyclic nitrones underwent molecular rearrangements, but 3-oxazoline N-oxides. would not react with 1,3-cyclo-addition type reagents.The synthesis of a wide variety of substituted 3-oxazolines has been accomplished by the reaction of ahydroxy ketones and aromatic aldehydes with ammonia in yields of 50-95 percent (2,3). N o additional work on the chemistry of this new type of heterocycle has been reported. I t was found that by treating these 3-oxazolines with rn-chloroperoxybenzoic acid in methylene chloride, they were converted to the corresponding N-oxides in 82-96 percent yields.
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