Records from the Multiple‐Institution Database for Investigating Engineering Longitudinal Development indicate that engineering students are typical of students in other majors with respect to: persistence in major; persistence by gender and ethnicity; racial/ethnic distribution; and grade distribution. Data from the National Survey of Student Engagement show that this similarity extends to engagement outcomes including course challenge, faculty interaction, satisfaction with institution, and overall satisfaction. Engineering differs from other majors most notably by a dearth of female students and a low rate of migration into the major. Noting the similarity of students of engineering and other majors with respect to persistence and engagement, we propose that engagement is a precursor to persistence. We explore this hypothesis using data from the Academic Pathways Study of the Center for the Advancement of Engineering Education. Further exploration reveals that although persistence and engagement do not vary as much as expected by discipline, there is significant institutional variation, and we assert a need to address persistence and engagement at the institutional level and throughout higher education. Finally, our findings highlight the potential of making the study of engineering more attractive to qualified students. Our findings suggest that a two‐pronged approach holds the greatest potential for increasing the number of students graduating with engineering degrees: identify programming that retains the students who come to college committed to an engineering major, and develop programming and policies that allow other students to migrate in. There is already considerable discourse on persistence, so our findings suggest that more research focus is needed on the pathways into engineering, including pathways from other majors.
Summary
Background Benefits and risks of concomitant immunomodulators and maintenance infliximab in inflammatory bowel disease (IBD) patients have not been adequately evaluated.
Aim To assess the effect of concomitant immunomodulator and infliximab maintenance therapy using data from four prospective, randomized Phase 3 trials in IBD patients.
Methods Overall, 1383 patients from ACCENT I and ACCENT II [luminal and fistulizing Crohn’s disease trials] and ACT 1 and ACT 2 [ulcerative colitis trials] were analysed. Patients were treated with placebo or infliximab 5 or 10 mg/kg at weeks 0, 2 and 6 followed by every‐8‐week maintenance therapy. Clinical response, clinical remission, fistula response, complete fistula response, infection and infusion reaction rates; serum infliximab concentrations and immunogenicity were summarized by baseline concomitant immunomodulator subgroup (use or non‐use).
Results Overall, almost 40% of evaluated IBD patients received concomitant immunomodulators. Efficacy, infection, and serious infection rates were generally similar in patients who received maintenance therapy with or without concomitant immunomodulators. There were no consistent differences in serum infliximab concentrations with or without immunomodulators in patients who received scheduled maintenance therapy. Concomitant immunomodulators reduced infusion reactions and immunogenicity.
Conclusion Concomitant immunomodulators did not improve efficacy or pharmacokinetics in IBD patients who received maintenance infliximab.
This study uses a mixed-methods design to investigate students' career decision making at two U.S. undergraduate institutions. The research question was, "To what extent do students who complete undergraduate programs in engineering intend to pursue engineering careers?" We surveyed senior engineering majors about their post-graduate intentions, and later interviewed a subset of the seniors about their career intentions. Only 42 percent of students surveyed reported that they definitely intended to pursue a career in engineering, 44 percent were unsure, and 14 percent were definitely not pursuing engineering. We observed significant institutional differences. Interview data reveal the quixotic nature of many students' decisions about their careers; strikingly, students were vacillating between multiple post-graduate options late into the senior year, even into summer. Implications are discussed for further research and ways engineering departments can influence students' career decisions.
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