Die Synthese der Titelverbindung (XIb) gelingt auf dem angegebenen Weg ausgehend von dem Ketoester (I) (Darstellung beschrieben); als Zwischenstufen bei diesem Syntheseweg treten das acs(= all‐cis‐syn)‐(Cs)‐C14‐Tetrachinan‐ (VI) und das C"‐Pentachinan‐System (VIII) auf.
Robust and scalable syntheses of some synthetically useful 3,5disubstituted phenols are presented. The process involves the selective displacement of a halogen by nucleophilic aromatic substitution using a preformed mixture of potassium tert-butoxide and p-methoxybenzyl alcohol (PMB-OH), followed by deprotection of the PMB ether with acid in the presence of 1,3-dimethoxybenzene. These processes have been demonstrated on kilogram scale, providing crystalline phenols in good yield and high purity.
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