Southwest Mexico City (SWMC) air pollution is characterized by high concentrations of ozone and particulate matter < 10 μm (PM10) containing lipopolysaccharides while in the North PM2.5 is high. These intra-city differences are likely accounting for higher CD14 and IL-1β in SWMC v NMC mice myocardial expression. This pilot study was designed to investigate whether similar intra-city differences exist in the levels of myocardial inflammatory genes in young people. Inflammatory mediator genes and inflammasome arrays were measured in right and left autopsy ventricles of 6 southwest/15 north (18.5 ± 2.6 years) MC residents after fatal sudden accidental deaths. There was a significant S v N right ventricle up-regulation of IL-1β (p=0.008), TNF-α (p=0.001), IL-10 (p=0.001), and CD14 (p=0.002), and a left ventricle difference in TNF-α (p=0.007), and IL-10 (p=0.02). SW right ventricles had significant up-regulation of NLRC1, NLRP3 and of 29/84 inflammasome genes, including NOD factors and caspases. There was significant degranulation of mast cells both in myocardium and epicardial nerve fibers. Differential expression of key inflammatory myocardial genes and inflammasomes are influenced by the location of residence. Myocardial inflammation and inflammasome activation in young hearts is a plausible pathway of heart injury in urbanites and adverse effects on the cardiovascular system are expected.

Manufacturing tolerances for laminar flow wings can be significantly tighter than those of conventional aircraft. The tighter tolerances can significantly affect the assessment of the practicality of designing for laminar flow. However, existing data on the effects of excrescences typical of manufacturing process are limited. Further, information on the effects-often beneficial-of pressure gradient present on the laminar flow wings is not generally available. To address these concerns, a series of experiments has been undertaken to examine the effects of surface steps in the presence of pressure gradients. The step geometries were selected to represent those that result from actual aircraft manufacturing processes. The range of pressure gradients correspond to those typical of laminar flow wings. Initial experiments were conducted in a low-speed wind tunnel. Later experiments used a novel propelled-model test facility. The results of these studies show that the allowable sizes of surface excrescences for laminar flow wings may be significantly greater than has conventionally been assumed. This could significantly influence the more widespread use of laminar flow for drag reduction, resulting in more efficient aircraft.

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This paper describes recent advances in the development of sol-iel-based pressure-sensitive paints (PSPs) for the idvestigation of low-speed-flow aerodynamics. Sol-gel-based materials are an attractive PSP binder matrix I,ecause of their robust material characteristics and compatibility with optical .

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Nature abounds with examples of animals which decrease their energy expenditure by gliding off the bow waves of large moving objects, riding thermals, or flying in efficient configurations. The past twenty years has seen significant advances in the scientific understanding and feasibility of large aircraft saving energy by flying in advantageous pair or triple geometries. Several recent flight tests demonstrated reductions in fuel burn for trailing aircraft of 10% or more. The energy savings can be converted into a variety of beneficial operational capabilities: extended range, increased loiter time, larger payload, cost savings, etc. The next looming challenge is operationalizing this practice. The discussion areas include: benefits, penalties, and trade-offs; operational modes; maneuvers; routing and scheduling; regulations; and the process of a deliberate, evolutionary approach in fielding this capability into existing aviation enterprises.