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Accurate pedestrian counting algorithm is critical to eliminate insecurity in the congested public scenes. However, counting pedestrians in crowded scenes often suffer from severe perspective distortion. In this paper, basing on the straightline double region pedestrian counting method, we propose a dynamic region division algorithm to keep the completeness of counting objects. Utilizing the object bounding boxes obtained by YoloV3 and expectation division line of the scene, the boundary for nearby region and distant one is generated under the premise of retaining whole head. Ulteriorly, appropriate learning models are applied to count pedestrians in each obtained region. In the distant region, a novel inception dilated convolutional neural network is proposed to solve the problem of choosing dilation rate. In the nearby region, YoloV3 is used for detecting the pedestrian in multi-scale. Accordingly, the total number of pedestrians in each frame is obtained by fusing the result in nearby and distant regions. A typical subway pedestrian video dataset is chosen to conduct experiment in this paper. The result demonstrate that proposed algorithm is superior to existing machine learning based methods in general performance.

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Pharmacophore-based virtual screening is an important and leading compound discovery method. However, current pharmacophore generation algorithms suffer from difficulties, such as ligand-dependent computation and massive extractive chemical features. On the basis of the features extracted by the five probes in Pocket v.3, this paper presents an improved receptor-based pharmacophore generation algorithm guided by atomic chemical characteristics and hybridization types. The algorithm works under the constraint of receptor atom hybridization types and space distance. Four chemical characteristics (H-A, H-D, and positive and negative charges) were extracted using the hybridization type of receptor atoms, and the feature point sets were merged with 3 Å space constraints. Furthermore, on the basis of the original extraction of hydrophobic characteristics, extraction of aromatic ring chemical characteristics was achieved by counting the number of aromatics, searching for residual base aromatic ring, and determining the direction of aromatic rings. Accordingly, extraction of six kinds of chemical characteristics of the pharmacophore was achieved. In view of the pharmacophore characteristics, our algorithm was compared with the existing LigandScout algorithm. The results demonstrate that the pharmacophore possessing six chemical characteristics can be characterized using our algorithm, which features fewer pharmacophore characteristics and is ligand independent. The computation of many instances from the directory of useful decoy dataset show that the active molecules and decoy molecules can be effectively differentiated through the presented method in this paper.

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