Amino acids U 0400
Synthesis of Pyrrolo[2,3-d]pyrimidine Analogues of the Potent Antitumor Agent N-{4-[3-(2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl}-L-glu-tamic Acid (TNP-351). -The novel three-atom-bridged analogues (III) and (VI) are synthesized via the key intermediate (I). Biological evaluation of the corresponding diacids reveals that both compounds are inactive in antiproliferative assay. -(ZHU, G.; LIU, Z.; XU, Y.; MAO*
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