Purpose: To evaluate the therapeutic effect of Epimedium brevicornum Maxim. extract (EBME) on ovariectomy-induced osteoporosis in rats.
Methods:The rats were divided into six experimental groups, viz, control (group 1)
ALP), urinary calcium (U-Ca), urinary phosphorus (U-P), urinary creatinine (U-SCr) and osteocalcin (OC) levels.
Result:The results showed that the BMD decrease induced by OVX in 4LV and femur was significantly mitigated by high dose of EBME. EBME also protected the trabecular microarchitecture against OVXassociated deterioration, evidenced by decreased bone turnover marker levels in 4LV at high EBME dose. 3.7 ± 0.2), trabecular thickness 0.082 ± 0.011), and trabecular spacing 0.17 ± 0.01)
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