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It is challenging to develop disposable optical biosensors due to the high cost and poor reproducibility. Here we report the disposable laser-based immunosensor enabled by mass-produced hollow optical fiber.

We investigate the potential of fabricating thermally stable refractive index contrasts using femtosecond (fs) near-infrared (IR) radiation in aluminosilicate glasses. A set of pure SiO 2-Al 2 O 3 glasses are manufactured, characterized (density and Raman) and investigated after being irradiated by fs laser within the Type II regime. The formation of nanogratings is identified and studied using quantitative birefringence measurements. Their thermal stability is then investigated through 30min step isochronal annealing (up to 1250°C). For both SiO 2 and 50SiO 2-50Al 2 O 3 compositions, the normalized birefringence does not decrease when tested up to 1100°C, while for the 4,6 mol% GeO 2-SiO 2 erased for 20% at 1000°C.