The tris(acetylacetonato)rhodium(III) catalyst is shown to be a versatile catalyst in the presence of DABCO (1,4‐diazabicyclo[2.2.2]octane) as ligand for the α‐alkylation of ketones followed by transfer hydrogenation, for the one‐pot β‐alkylation of secondary alcohols with primary alcohols and for the alkylation of aromatic amines in the presence of an inorganic base in toluene.
Direct ortho C–H monoarylation of 2-phenylpyridine and 1-phenyl-1H-pyrazole and its derivatives via a Ru catalysed reaction using catalytic amount of Phl(OCOCF3)2 as a hyper-valent iodine oxidant with arylboronic acids is presented.
A concise, simple, and efficient method for remote C–H bond halogenation (Br and Cl) of 8‐aminoquinoline scaffolds at the geometrically difficult‐to‐access C5 position was explored with diverse substrate combinations in DMF. This protocol made use of inexpensive CuBr2 and CuCl2 as mediators and showed good to excellent yields for as many as 24 substrate combinations. The outstanding site selectivity of the reaction was reflected by the lack of formation of the undesired C7‐halogenated byproduct originating from the high nucleophilic reactivity of the 8‐aminoquinoline scaffold at the C7 position, even if excess amounts of the CuX2 salts were used.
A practical method for PhI(OCOCF3)2 mediated direct meta-C–H monohalogenation of 2-phenylpyridine and its derivatives via an Ru(i) catalyzed reaction is reported.
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