Objective We aimed to assess urinary leukotriene (ULT) changes during asthma attacks and to evaluate the effect of anti-inflammatory drugs on ULT levels.Methods A randomized prospective case-control study was mediated. The study included 30 asthmatic patients (19 male and 11 female), aging 8-14 years. Patients were diagnosed as partly controlled asthmatic individuals. Twenty age-matched and sex-matched healthy children were also included as controls. Participants were subjected to thorough history taking, clinical examination, pulmonary function testing, ULTB4 assessment and blood eosinophilic count. Medical treatment for 6 weeks was mediated. Tests were repeated for evaluation. ResultsSignificant improvement was noted with regard to the spirometric parameters FEV1%, FVC%, PEFR% and FEF 25-75% (P < 0.001, 0.020, 0.0005, and 0.0005, respectively). The blood eosinophilic count decreased (P = 0.0002). ULTB4 levels decreased from 70.40 to 44.09 pg/ml (P = 0.0001) with leukotriene receptor antagonist treatment. The inhaled corticosteroid group also showed significant improvement. There was improvement in spirometric values and a better eosinophilic count in the inhaled corticosteroid group, whereas ULTB4 improvement was better in the leukotriene receptor antagonist group. Yet, the difference between the two groups did not reach a significant value.Conclusion Using the receiver-operating characteristic curve for the evaluation of asthma, ULTB4 was as a reliable marker for asthma monitoring and follow-up.
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