Assessment of the effectiveness of treatment and recovery of reproductive functions of cows with fatty liver decease using a drug based on a healthy liver hydrolysate (the enzyme structures of the protein after acid treatment and centrifugation remain in the sediment of the tissue substrate, and their released amino acids become constituent components of the over-sediment solution of the hydrolysate). Two groups of animals of 15 heads each were formed: first-calf heifers entered the first group on the first day after calving, liver pathology was indicated by an increase in its borders during percussion, and animals with clinical signs of deep fatty liver disease were included in the second group a month after calving. The dose was 40 ml daily (20 ml intramuscularly and 20 ml subcutaneously), the course of treatment was 5 days. After the 1st stage, the remaining 25 cows of both groups were considered as one experimental group of the 2nd stage, which was periodically monitored until the next calving and insemination; the control was 25 animals not subjected to hepatoprotective therapy. Cows that underwent even one treatment procedure were better adapted to the newborn period and subsequent insemination. They have faster involution of the uterus and the resumption of the sexual cycle (P <0.001), higher fertility, and a greater number of healthy calves.
Probiotics are known for their beneficial effects on poultry health and wellbeing. One promising strategy for discovering Bacillus probiotics is selecting strains from the microbiota of healthy chickens and subsequent screening for potential biological activity. In this study, we focused on three probiotic strains isolated from the gastrointestinal tract of chickens bred in different housing types. In addition to the previously reported poultry probiotic Bacillus subtilis KATMIRA1933, three strains with antimutagenic and antioxidant properties Bacillus subtilis KB16, Bacillus subtilis KB41, and Bacillus amyloliquefaciens KB54, were investigated. Their potential effects on broiler health, growth performance, and the immune system were evaluated in vivo. Two hundred newly hatched Cobb500 broiler chickens were randomly divided into five groups (n = 40). Four groups received a standard diet supplemented with the studied bacilli for 42 days, and one group with no supplements was used as a control. Our data showed that all probiotics except Bacillus subtilis KATMIRA1933 colonized the intestines. Treatment with Bacillus subtilis KB54 showed a significant improvement in growth performance compared to other treated groups. When Bacillus subtilis KB41 and Bacillus amyloliquefaciens KB54 were applied, the most significant immune modulation was noticed through the promotion of IL-6 and IL-10. We concluded that Bacillus subtilis KB54 supplementation had the largest positive impact on broilers' health and growth performance.
The nature of the mineral supply of certain biogeochemical provinces and their correlative interactions within biological organisms determine the degree of development of immunosuppressive states in animals. So we studied the level of minerals in the samples of hair and blood in cattle in the «mother-offspring» system and established the nature of the correlation of cobalt, zinc, iron and copper. It has been proven that low levels of cobalt (cows - 429.30 ± 4.05 nmol/l and calves - 430.80 ± 5.60 nmol / L) and zinc (cows - 7.21 ± 0.20 pmol/l and calves - 7.60 ± 0.15 pmol/l) against the threshold values of iron (cows - 17.90 ± 1.30 pmol/l and calves - 18.40 ± 1.80 pmol/l) and copper (cows - 13.90 ± 1.80 pmol/l and calves - 14.08 ± 1.05 pmol/l) in the blood caused hematopoietic function impairment and led to the development of mild hypochromic anemia (erythrocytes: cows - 6.01 ± 0.40x1012/l and calves - 6.36±0.50x1012/l) in animals in the «mother-offspring» system. In addition, metabolic disorders caused by nutritional deficiency of zinc contributed to a decrease in the synthesis of alkaline phosphatase (cows - 87.90 ± 5.10 U/l and calves - 126.80±4.02 U/l), exacerbating the disorder of erythropoietic function of red bone animal brain. A long-term imbalance of copper and zinc in the nutrient substrates of the studied animals was revealed, as evidenced by the results of a mineralogram of hairline samples (copper: cows - 13.910 ± 0.67 mg/kg and calves - 12.609 ± 0.70 mg/kg; zinc: cows - 57.960 ± 0.90 mg/kg and calves 60.315 ± 0.99 mg/kg), which ultimately led to a deficiency of zinc in the body, leading to the development of an immunosuppressive state (Ig M: cows - 0.99 ± 0.15 mg/ml and calves - 1.64 ± 0.05 mg/ml; Ig A: cows - 0.30 ± 0.05 mg/ml and calves - 2.05 ± 0.10 mg/ml).
In view of the potential global human factors threats, NBIC convergence in manufacturing systems requires new, sustainable approaches to HR management. The proposed methodology is based on the systems paradigm of Janos Kornai, which is used in the framework of BigData technologies, artificial intelligence, and blockchain. The problem of control, optimization and evolution of the human factor in NBIC-production cyber-physical systems is solved by means of the developed human-oriented concept of HR-resources management, the development of which occurs in a spiral, involving exit from the system to form new meanings and concepts. Each turn of the spiral is a self-organizing system. For the current stage of development, a cyber-physical system of interaction “Man” - “Machine” is proposed, based on global and double iterative connections, parallel analysis, scenario forecasting, machine learning, cognitive component and collective decision making. The developed human-oriented concept of HR-resources management allows you to control, optimize and develop human production activities, ensure iterative self-development and self-improvement of the system, guarantee the stability and safety of the system, maximize the percentage of return on human resources and reduce the level of opportunistic human behavior.
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