Hyperpolarized (hp) 129Xe and hp 83Kr for magnetic resonance imaging (MRI) are typically obtained through spin-exchange optical pumping (SEOP) in gas mixtures with dilute concentrations of the respective noble gas. The usage of dilute noble gases mixtures requires cryogenic gas separation after SEOP, a step that makes clinical and preclinical applications of hp 129Xe MRI cumbersome. For hp 83Kr MRI, cryogenic concentration is not practical due to depolarization that is caused by quadrupolar relaxation in the condensed phase. In this work, the concept of stopped flow SEOP with concentrated noble gas mixtures at low pressures was explored using a laser with 23.3 W of output power and 0.25 nm linewidth. For 129Xe SEOP without cryogenic separation, the highest obtained MR signal intensity from the hp xenon-nitrogen gas mixture was equivalent to that arising from 15.5±1.9% spin polarized 129Xe in pure xenon gas. The production rate of the hp gas mixture, measured at 298 K, was 1.8 cm3/min. For hp 83Kr, the equivalent of 4.4±0.5% spin polarization in pure krypton at a production rate of 2 cm3/min was produced. The general dependency of spin polarization upon gas pressure obtained in stopped flow SEOP is reported for various noble gas concentrations. Aspects of SEOP specific to the two noble gas isotopes are discussed and compared with current theoretical opinions. A non-linear pressure broadening of the Rb D1 transition was observed and taken into account for the qualitative description of the SEOP process.
For the first time, magnetic resonance imaging (MRI) with hyperpolarized (hp) krypton-83 ( 83 Kr) has become available. The relaxation of the nuclear spin of 83 Kr atoms (I ؍ 9͞2) is driven by quadrupolar interactions during brief adsorption periods on surrounding material interfaces. Experiments in model systems reveal that the longitudinal relaxation of hp 83 Kr gas strongly depends on the chemical composition of the materials. The relaxationweighted contrast in hp 83 Kr MRI allows for the distinction between hydrophobic and hydrophilic surfaces. The feasibility of hp 83 Kr MRI of airways is tested in canine lung tissue by using krypton gas with natural abundance isotopic distribution. Additionally, the influence of magnetic field strength and the presence of a breathable concentration of molecular oxygen on longitudinal relaxation are investigated.NMR ͉ optical pumping ͉ pulmonary ͉ MRI ͉ xenon H igh nuclear spin polarization in noble gasses can be generated through rubidium vapor spin exchange optical pumping (RbSEOP) (1) and allows for NMR signal enhancements of many orders of magnitude (2). Hyperpolarized (hp) 3 He and hp 129 Xe (both I ϭ 1͞2) have both been used in a wide range of NMR and magnetic resonance imaging (MRI) experiments that are otherwise impossible (3-15). In particular hp 3 He has been applied for medical MRI diagnosis of pulmonary diseases (16)(17)(18)(19). One of the fundamental parameters with high diagnostic value for hp 3 He MRI is the spin-density that is a result of the helium concentration in a particular volume. Spin-density mapping of hp 3 He can be applied to visualize ventilation in lungs. Other useful parameters are 3 He diffusion that provides information about alveolar size distributions in lung tissue and hp 3 He relaxation that depends on oxygen partial pressure in lungs. In vivo MRI of airways with hp 129 Xe as a contrast agent (19-21) suffers from a lower sensitivity compared with hp 3 He. However, 129 Xe adds a further parameter not available by 3 He, namely, the chemical shift that allows for insights into the local environment of the xenon atoms (22-27). The 129 Xe chemical shift has been used extensively for research in materials science, engineering, and xenon dissolved in liquids including human blood (3,5,6,8,9,12,28). The chemical shift obtained from hp 129 Xe can be used to generate an in vivo MRI contrast that is a probe for gas perfusion in lungs (i.e., exchange of the gaseous xenon with the lung parenchyma) (29).3 He and 129 Xe are the only spin I ϭ 1͞2 stable isotopes of the noble gas group, but there are three more NMR active isotopes in this group with higher spin that possess a nuclear electric quadrupole moment. The three quadrupolar isotopes are 21 Ne (I ϭ 3͞2, natural abundance 0.27%), 83 Kr (I ϭ 9͞2, natural abundance 11.5%), and 131 Xe (I ϭ 3͞2, natural abundance 21%). Quadrupolar interactions in these noble gas atoms cause spin relaxation and coherent spin evolution that are probes for the shape, size, and symmetry of void spaces as well as the ...
Graphical abstractHighlights► Advances in hyperpolarization have reduced the SNR gap between 3He and 129Xe. ► 129Xe offers additional information useful in materials and biomedical sciences. ► Non-invasive techniques with 129Xe probe lung morphometry and offer new biomarkers. ► 83Kr with a nuclear electric quadrupole moment provides surface sensitive contrast.
Sodium-ion batteries are a promising battery technology for their cost and sustainability. This has led to increasing interest in the development of new sodium-ion batteries and new analytical methods to non-invasively, directly visualise battery chemistry. Here we report operando 1 H and 23 Na nuclear magnetic resonance spectroscopy and imaging experiments to observe the speciation and distribution of sodium in the electrode and electrolyte during sodiation and desodiation of hard carbon in a sodium metal cell and a sodium-ion full-cell configuration. The evolution of the hard carbon sodiation and subsequent formation and evolution of sodium dendrites, upon over-sodiation of the hard carbon, are observed and mapped by 23 Na nuclear magnetic resonance spectroscopy and imaging, and their threedimensional microstructure visualised by 1 H magnetic resonance imaging. We also observe, for the first time, the formation of metallic sodium species on hard carbon upon first charge (formation) in a full-cell configuration.
Gas mixtures with high xenon densities are explored for continuous flow spin-exchange optical pumping. It is shown that the Xe-NMR129 signal increases significantly with increasing xenon partial pressures up to about 200 kPa, despite a decreasing spin-polarization. Comparison of the rubidium infrared D2 emission with the xenon polarization demonstrates that radiation quenching by molecular nitrogen is of no substantial benefit for the pumping process at xenon pressures above 100 kPa. This reflects a diminished importance of spin-depolarization by radiation trapping due to the increased significance of spin-relaxation by rubidium-xenon collisions at high xenon densities. A quantitative expression for this effect is provided.
For the first time, a hyperpolarized (hp) noble gas with a nuclear electric quadrupole moment is available for high-field nuclear-magnetic-resonance (NMR) spectroscopy and magnetic-resonance imaging. Hp (83)Kr (I=92) is generated by spin-exchange optical pumping and separated from the rubidium vapor used in the pumping process. Optical pumping occurs under the previously unstudied condition of high krypton gas densities. Signal enhancements of more than three orders of magnitude compared to the thermal equilibrium (83)Kr signal at 9.4 T magnetic-field strength are obtained. The spin-lattice relaxation of (83)Kr is caused primarily by quadrupolar couplings during the brief adsorption periods of the krypton atoms on the surrounding container walls and significantly limits the currently obtained spin polarization. Measurements in macroscopic glass containers and in desiccated canine lung tissue at field strengths between 0.05 and 3 T using remotely detected hp (83)Kr NMR spectroscopy reveal that the longitudinal relaxation dramatically accelerates as the magnetic-field strength decreases.
In this proof of principle work, a technique is introduced to study hydrated surfaces using hyperpolarized (hp) 83Kr NMR spectroscopy. The longitudinal (T1) relaxation of hp-83Kr is shown to be extremely sensitive to the presence of adsorbed water on hydrophilic borosilicate and hydrophobic siliconized glass surfaces. The krypton surface relaxation is found to be largely independent of the total gas pressure applied to the studied materials, and the presented technique is therefore fairly robust. However, the relaxational properties of hp-83Kr can be "tuned" by adjusting the composition of the optical pumping gas mixture. This effect may be important for practical applications such as hp-83Kr MR imaging and can be achieved without sacrificing signal intensity. Complementary information to that of hp-83Kr surface relaxation data can be obtained from hp-129Xe relaxation measurements that are sensitive to the presence of paramagnetic surface sites. In contrast to the signal decay of hp-129Xe, the longitudinal relaxation of 83Kr is largely unaffected by paramagnetic impurities, and in some materials, 83Kr and 129Xe show comparable T1 times that are caused by two completely different relaxation mechanisms. Finally, the relaxation times of 83Kr in contact with bovine lung surfactant coated glass pores that are similar in size to mammalian alveoli are presented. The results suggest that in vivo MR studies may be feasible and could provide valuable information about changes in pulmonary surface chemistry.
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