An Improved Two-Step Regioselective Synthesis of Naphth[1,2-b]and Naphth[2,1-b]oxepin-5-ones.-Compared to known procedures for the synthesis of pharmacologically interesting products (IV) and (VII), the method reported comprises fewer reaction steps, shorter reaction times and affords higher yields. -(TANDON, V. K.; CHHOR, R. B.; GOSWAMY, G. K.; Indian J.
Compounds. -The preparation of title compounds (VIII) and (XIII) involving a two-step regioselective synthesis of naphthoxepin-5-one derivatives (IV) and (XI), resp., as key step and their pharmacological evaluation are reported. Compounds (VIIIb) and (VIIIc) show promising hypotensive activity. -(TANDON*, V. K.; KUMAR, M.; AWASTHI, A. K.; SAXENA, H. O.; GOSWAMY, G. K.; Bioorg. Med. Chem. Lett. 14 (2004) 12, 3177-3180; Dep. Chem., Lucknow Univ., Lucknow 226 007, India; Eng.) -M. Schroeter 40-168
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