111In является одним из наиболее употребляемых диагностических изотопов. Обсуждается возможность получения 111In из мишеней 114Sn и 112Sn. Анализ проведен на основе расчетных данных, полученных с использованием кода TALYS-1.95. В то время как облучение мишени 114Sn приводит к крайне низкому выходу 111In, реакция 112Sn(p,x) является перспективной из-за высоких выходов непрямых каналов образования. Согласно результатам моделирования выход 111In в реакции 112Sn(p,x) выше, чем в коммерчески используемой реакции 111Cd(p,n) 111In, и сравним с выходом в реакции 112Cd(p,2n)111In. 111In is an important diagnostic medical radioisotope. We discuss the possibility of its production from 114Sn and 112Sn targets in proton-induced reactions. Analysis made on the base of TALYS-1.95 calculations. While the irradiation of 114Sn target leads to unfeasibly low yield of 111In, 112Sn(p,x) production route is promising because of high yields of indirect production channels. According to simulation results, the yield of 111In in 112Sn(p,x) reactions is higher than in the commercially used reaction 111Cd(p,n) 111In and is comparable to yield in 112Cd(p,2n) 111In reaction.
В статье рассмотрены (y,n) и (y,p) реакции на ядрах 46,48,50Ti, 58,60Ni и 48Ca в области энергий гигантского дипольного резонанса. Проведены расчеты на основе кода TALYS 1.95 и сравнены с экспериментальными данными, существующими в литературе. Исследование выявило определенные расхождения в описании фотопротонных реакций. Расхождение увеличивается с ростом числа нейтронов мишеней. Для лучшего описания сечений этих реакций необходим учет изоспинового расщепления ГДР при расчетах. Հոդվածում դիտարկվում են (y,n) և (y,p) ռեակցիաները 46,48,50Ti, 58,60Ni և 48Ca թիրախների վրա հսկա դիպոլային ռեզոնանսի (ՀԴՌ) էներգետիկ տիրույթում։ Հաշվարկներն իրականացվել են TALYS 1.95 կոդի հիման վրա և հաշվարկված տվյալները համեմատվել են գրականության մեջ առկա փորձարարական տվյալների հետ: Ուսումնասիրությունները բացահայտեցին որոշակի անհամապատասխանություններ ֆոտոպրոտոնային ռեակցիաների նկարագրության մեջ։ Անհամապատասխանությունը մեծանում է թիրախում նեյտրոնների քանակի աճին զուգընթաց։ Այս ռեակցիաների կտրվածքների ավելի լավ նկարագրության համար անհրաժեշտ է հաշվի առնել ՀԴՌ -ի իզոսպինային ճեղքումը: The article considers (y,n) and (y,p) reactions on 46,48,50Ti, 58,60Ni and 48Ca nuclei in the energy range of giant dipole resonance. Calculations were carried out on the basis of the TALYS 1.95 code and the calculated data were compared with the experimental data available in the literature. The study revealed certain discrepancies in the description of photo-proton reactions. The discrepancy increases with the number of target neutrons. For a better description of the cross sections for these reactions, it is necessary to take into account the isospin splitting of the GDR in calculations.
Background. Two-stage revision arthroplasty remains the main surgical strategy for the treatment of prosthetic joint infections (PJI). Sonicate fluid culture has improved sensitivity compared to standard periprosthetic tissue culture, but its usefulness is questionable during the second stage of revision arthroplasty. Material and methods. Twenty-seven patients with prosthetic joint infection were investigated. Tissue and sonicate fluid cultures were examined to detect bacteria on the removed spacer during the second stage of exchange arthroplasty. Microbiological findings were analyzed and patients were assessed within an average of 5 years’ follow up. Results. Tissue cultures in second-stage revision arthroplasties were positive in 6/27 cases (22.2%) growing CNS in 4 cases (14.8%), Staphylococcus aureus in 1 case (3.7%), and Enterococcus faecalis in 1 case (3.7%). In 3 cases (11.1%) infection was identified as a result of a sonication procedure. Clinical failures at final follow-up were recorded in 4 (14.8%) patients, with reinfection noted in 3 of them. Arthrodesis and spacer exchange followed by suppressive antibiotic therapy were performed in 2 cases. Conclusions. 1. Tissue cultures remain the gold standard in diagnosis of PIJ although a negative culture does not rule out the presence of bacteria on spacers removed during second stage revision for PJI. 2. Sonication appears to have limited ability to detect persistent infection before reimplantation and was not associated with recurrent infection; however, it can be considered a complementary method that could make it possible to identify new microorganisms and facilitate the selection of appropriate treatment options. 3. The positive results of sonication should be interpreted as the detection of actual pathogens in the light of the clinical, microbiological and histopathological data, especially for patients with immunodeficiency.
A new temperate phiCDKH01 siphophage was obtained from clinical isolate of Clostridioides difficile. The phage genome is a 45,089 bp linear double-stranded DNA molecule with an average G + C content of 28.7%. It shows low similarity to known phage genomes except for phiCD24-1. Genomic and phylogenetic analysis revealed that phiCDKH01 is a novel phage. 66 putative ORFs were predicted in the genome, 37 of which code for proteins with predicted functions. The phiCDKH01 prophage has been localized in the host genome. Results of this study increases genetic diversity of known tailed phages.
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