Gentamicin absorption was measured after oral administration in 18 neonates treated prophylactically in an attempt to decrease the incidence of necrotizing enterocolitis. Patients were given 10 mg/kg/day in four divided doses via nasogastric tube for a total of 10 days. Levels were assayed using the Emit system. Serum levels ranged between 0 and 2.2 μg/ml. Mean levels over 10 days were 0.42 ± (SD) 0.47 μg/ml and did not vary significantly from day to day. From these data we conclude that enterally administered gentamicin is not absorbed to a degree that would result in toxic or even therapeutic serum concentrations.
Early structural defects have an increased incidence in monozygous (MZ) twins and are nonconcordant in about 80% of all cases. This has led to the conclusion that early structural malformations in one of MZ twins, and the MZ twinning process itself, are causally linked [Schinzel et al, 19791. The causal link is hypothesized to be a midline field defect [Opitz, 19821. We have recently observed a set of triplets, most likely monozygous, who are discordant for normality (triplet A), holoprosencephaly (triplet B) , and fetus papyraceous (Triplet C). We think these infants provide additional support for the hypothesis that monozygosity and early structural defects in monozygotic twins are cleavage disorders of the midline field.
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