Chromoblastomycosis is a chronic fungal infection of the epidermis, dermis and
subcutaneous tissue, in which the most common etiologic agent in Brazil is
Fonsecaea pedrosoi. In more advanced cases we found many
difficulties in their treatment, and therefore, we report a case of extensive
and severe chromoblastomycosis, with therapeutical failure of first choice
treatments, but good response to voriconazole.
Cryptococcosis is a fungal infection of opportunistic behavior that is unusual in
immunocompetent patients. We report a rare case of disseminated cryptococcosis
with cutaneous involvement in an immunocompetent individual. During
hospitalization, Cryptococcus gattii was isolated from skin
lesions, lung and spinal fluid. The diagnosis of disseminated
cryptococcosis was confirmed and treatment was established.
The patient showed improvement. Due to the probable clinical severity of the
disease and the possibility that skin lesions may be the first manifestation of
this illness, prompt diagnosis must be established and treatment provided.
Basal cell carcinoma is the most common malignant neoplasm in humans, with low mortality, high morbidity, and exposure to solar radiation (UVB and UVA) is the most critical risk factor. Ultraviolet B rays generate mutagenic photoproducts in DNA and mutations in important genes regulating cellular functions, such as the tumor suppressor gene TP53. Ultraviolet A rays generate cytotoxic and mutagenic free radicals, potentiating the effects of UVB rays.. There is current evidence to support the role of inflammatory biomarkers related to tumorigenesis of basal cell carcinoma.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.