Prevention of neurodegeneration during aging, and support of optimal brain function throughout the lifespan, requires protection of membrane structure and function. We review the synergistic action of different classes of dietary micronutrients, as well as further synergistic contributions from exercise and stress reduction, in supporting membrane structure and function. We address membrane-associated inflammation involving reactive oxygen species (ROS) that produce immune regulators from polyunsaturated fatty acids (PUFAs) of membrane phospholipids. The potential of dietary micronutrients to maintain membrane fluidity and prevent chronic inflammation is examined with a focus on synergistically acting membrane-soluble components (zeaxanthin, lutein, vitamin E, and omega-3 PUFAs) and water-soluble components (vitamin C and various phenolics). These different classes of micronutrients apparently operate in a series of intertwined oxidation-reduction cycles to protect membrane function and prevent chronic inflammation. At this time, it appears that combinations of a balanced diet with regular moderate exercise and stress-reduction practices are particularly beneficial. Effective whole-food-based diets include the Mediterranean and the MIND diet (Mediterranean-DASH Intervention for Neurodegenerative Delay diet, where DASH stands for Dietary Approaches to Stop Hypertension).
Hirundo is the most species-rich genus of the passerine swallow family (Hirundinidae) and has a cosmopolitan distribution. Here we report the complete, annotated mitochondrial genomes for 25 individuals from 10 of the 14 extant Hirundo species; these include representatives from four subspecies of the barn swallow, H. rustica. Mitogenomes were conserved in size, ranging from 18,500 to 18,700 base pairs. They all contained 13 protein-coding regions, 22 tRNAs, a control region, and large and small ribosomal subunits. Phylogenetic analysis resolved most of the relationships between the studied species and subspecies which were largely consistent with previously published trees. Several new relationships were observed within the phylogeny that could have only been discovered with the increased amount of genetic material. This study represents the largest Hirundo mitochondrial phylogeny to date, and could serve as a vital tool for other studies focusing on the evolution of the Hirundo genus.
Objectives Length at 2y of age is a strong indicator of adult height and potential for other adverse effects in adulthood; leg length (LL) is suggested to be the more nutritionally responsive component of height. These analyses examine body proportions- measured as linear crown rump length (CRL), LL, and CRL: LL- among 24 mo old children from four low- and middle-income settings with high stunting rates (average across 4 sites = 65%) participating in the Women First Preconception Maternal Nutrition Trial (WF). Methods The WF study is a nutrition intervention trial of maternal-child pairs in four diverse research sites (Democratic Republic of the Congo [DRC], Guatemala, India, and Pakistan). At 24 mo of age, toddler length and CRL were obtained and subsequently used to calculate LL (length-CRL). ANOVAs with post hoc Tukey HSD for each parameter were performed in JMP Pro 16.0.0. Results No statistical differences were seen by maternal intervention arm, thus anthropometric data from 2,157 children (DRC n = 488, Guatemala n = 540, India n = 531, Pakistan n = 598) were explored by site. While mean (±SD) CRL did not significantly differ between Guatemala and India (48.9 ± 2.18, 48.9 ± 2.30cm), Pakistan and DRC (47.7 ± 2.52, 45.8 ± 2.22cm) had significantly lower mean CRL (p < 0.001), with DRC having the lowest value. Mean LL did not differ significantly between Guatemala and Pakistan (30.6 ± 1.74, 30.5 ± 2.21), nor between DRC and India (32.6 ± 2.28, 32.3 ± 2.01cm); however, DRC and India had significantly longer mean LL vs Guatemala and Pakistan (p < 0.0001). Statistically significant differences in mean CRL: LL (p < 0.0001) were observed among all four sites, with Guatemala exhibiting the largest mean (1.60 ± 0.09), attributable to shorter LL. Conclusions CRL and LL are indicative of proportionality, a measure of impaired growth. These data highlight that among the four research sites in the WF trial, Guatemala, which exhibits the highest rate of maternal stunting, has the least favorable body proportions (largest CRL: LL). The difference in body proportions between sites despite nutritional intervention warrants further examination of genomic and environmental (including nutritional) factors that may have an effect on anthropometrics such as LL, CRL, and CRL: LL. Funding Sources Bill & Melinda Gates Foundation, NIH NICHD/ODS.
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