Despite the high incidence of breast cancer, there are few pharmacological prevention strategies for the high-risk population and those that are available have low adherence. Strategies that deliver drugs directly to the breasts may increase drug local concentrations, improving efficacy, safety and acceptance. The skin of the breast has been proposed as an administration route for local transdermal therapy, which may improve drug levels in the mammary tissue, due to both deep local penetration and percutaneous absorption. In this review, we discuss the application of nanotechnology-based strategies for the delivery of well established and new agents as well as drug repurposing using the topical transdermal route to improve the outcomes of preventive therapy for breast cancer.
Veiculação tópica de endoxifeno e celecoxibe utilizando nanocarreadores como uma nova alternativa para a prevenção do câncer de mama Dissertação apresentada ao Programa de Pósgraduação em Farmacologia do Instituto de Ciências Biomédicas da Universidade de São Paulo para a obtenção do título de Mestre em Ciências. Área de concentração: Farmacologia Orientadora: Profª. Drª. Luciana Biagini Lopes Versão corrigida São Paulo 2021 RESUMO Mojeiko G. Veiculação tópica de endoxifeno e celecoxibe utilizando nanocarreadores como uma nova alternativa para a prevenção do câncer de mama. Dissertação (Mestrado em Farmacologia).
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