Anorexia nervosa (AN) is a relatively common disorder, especially in adolescent and young adult women. The lifetime prevalence of AN in females ranges from 1.2 to 2.2%. The prevalence in males is 10-times lower. The condition is associated with a high risk of chronic course and poor prognosis in terms of treatment and the risk of death. Longer follow-up periods seemed to correspond with increased improvement rates and increased mortality. Onset of the disorder during adolescence is associated with better prognosis. It is reported that as much as 70% to over 80% of patients in this age group achieve remission. Worse outcomes are observed in patients who required hospitalization and in adults. Recent studies indicate improved prognosis for cure and lower mortality rates than previously reported. However, the recovery can take several years and AN is associated with high risk of developing other psychiatric disorders during the patients' lifetime, even after recovery from AN (mainly: affective disorders, anxiety disorders, obsessive-compulsive disorders, substance abuse disorders). Studies indicate that bulimic symptoms often occur in the course of anorexia nervosa (especially within 2-3 years from the onset of AN). The authors present a review of literature on the course, comorbidity, mortality, and prognostic factors in AN. Better knowledge of the course of anorexia can contribute to more realistic expectations of the pace of symptomatic improvement, as well as to a creation of therapeutic programs which are better adapted to the needs of the patients.

Objective: Total body and lumbar spine bone mineral density (BMD-TB, BMD-L) and total body bone mineral content (BMC-TB) were measured to establish the course of bone demineralization in anorexia nervosa and the clinical factors in¯uencing BMC-TB and BMD changes during treatment. Method: Forty-two girls with DSM III-R anorexia nervosa, age 14.7t2.4 years. BMC-TB, BMD-TB and BMD-L were measured in approximately 7-month intervals for 27.8t4.1 months using DXA. Results: Despite nutritional improvement, there was an initial decrease of BMD-L, and no change in BMC-TB and BMD-TB. an increase in BMC-TB and BMD was observed after approx. 21 months from the beginning of the study.

Pellagra is a potentially fatal, nutritional disease with cutaneous, gastrointestinal, and neuropsychiatric manifestations. Because of the diversity of pellagra's signs and symptoms, diagnosis is difficult without an appropriate index of suspicion. A case of pellagra in a 14-year-old girl with anorexia nervosa is presented. Signs and symptoms of pellagra were resolved after niacin therapy and dietary treatment.

FC66. OCD and eating disorders: biology and epidemiology condition. There are few systematic studies in nonclinical child and adolescents population. On the basis of these epidemiological data it is concluded that OCD is far more common then was previously believed. However, good epidemiological studies in other parts of the world than the US are still needed. Objective: To investigate the frequency of OCD and subclinical OCD in polish young adolescents. Method: During a two-stage epidemiological study, a total number of2884 pupils in Warsaw (Poland), aged 12-16 years completed the Leyton Obsessional Inventory-Child Version, consisting of 20 items. In the diagnostic stage the author's questionnaire based on DSM-IV diagnostic criteria for OCD and the Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS) were administrated to 96 subjects reflecting possible subclinical or clinical OCD and 52 subjects from control cohort. Results: The prevalence of OCD and subclinical OCD were found to be 0.38% and 2%, respectively. Conclusion: Findings suggest that obsessions, compulsions and OCD are not infrequent among young adolescents and the disorder usually is not seen or recognized by health care professionals.

The results show that there is a connection between obsessive-compulsive symptoms and the hyperactivity in AN patients.