Bovine papillomavirus (BPV) can cause damage to the epithelial and mucosal tissue and currently presents 28 known types. Not all BPV types are associated with the development of cancer in cattle. Studies have shown that variants of human papillomavirus types can present different pathogenic profiles. However, despite the similarity, it is not yet known whether variants of BPV types can also present varying degrees of pathogenicity. Thus, the aim of this study was to evaluate the genetic variability of BPV types and variants isolated in Northeastern Brazil. Samples were obtained from animals with papillomatous lesions. BPV DNA was detected by the amplification of the L1 gene and genotyping was performed by sequencing. Mutations were analyzed in a phylogenetic, structural and functional context. In total, 52 positive samples were obtained and 11 different BPV types were identified in the samples. Ten putative new BPV types were also identified. In addition, several non-synonymous mutations were identified and predicted to alter protein stability, having an impact on immune evasion. The study demonstrated a high genetic diversity of BPV in the region with a large number of mutations identified, serving as a basis for more efficient control measures to be adopted for bovine papillomatosis.
Objective to determine the effects of a simple home-based exercise program on functional capacity and perceived loneliness of older adults in lockdown due to the COVID-19 pandemic. Method Twenty-nine volunteers were randomly divided into two groups: (1) control group (CG); and (2) home-based exercise group (HBEG). Lower limb muscle strength, functional capacity, and perceived loneliness were assessed at baseline (pre-test), 4 weeks, and 8 weeks (post-test) using the Chair Standing Test (CST), Gait Speed Test (GST), Timed Up and Go test (TUG), and Perceived Loneliness Scale (PLS). Results The number of repetitions on the CST differed statistically between the groups (CG vs. HBEP, p=0.006) and among timepoints (Pre vs. 4W vs. 8W, p=0.043.). In the CG group, TUG test completion time was statistically lower at baseline than at 8 weeks (p=0.021) (pre 12.0±5.9 s vs. 8W 12.7±6.5 s). There was no statistical difference in TUG time in the HBEG. No statistical differences were found on the GST and PSL between groups or among timepoints. Conclusion The home-based exercise program improved general functional capacity after 8 weeks of training, but perceived loneliness and gait speed were unchanged in the older adults experiencing lockdown due to the COVID-19 pandemic.
Resumo Objetivo Determinar os efeitos de um programa de exercício físico remoto realizado em ambiente domiciliar na capacidade funcional e percepção de solidão de idosos socialmente isolados, devido a pandemia da covid-19. Método Vinte e nove (29) idosos foram divididos aleatoriamente em dois grupos: (1) grupo controle (GC) e grupo de exercício em ambiente domiciliar (GEAD). A força muscular dos membros inferiores, a capacidade funcional e a percepção de solidão foram avaliadas no início (pré-teste), 4 semanas e 8 semanas (pós-teste). As avaliações consistiram no teste de sentar e levantar da cadeira (TSL), teste de velocidade de marcha (TVM), Timed Up and Go (TUG) e teste de percepção de solidão (TPS). Resultados O número de repetições durante o TSL foi estatisticamente diferente entre os grupos (GC vs. GEAD, p=0,006 e entre os momentos (Pré vs. 4S vs. 8S, p=0,043.). No teste de TUG, dentro do GC, o momento pré foi estatisticamente menor em relação ao momento de 8 semanas (p<0,021), indicando maior tempo para completar o TUG (pré 12,0±5,9 s vs. 8W 12,7±6,5 s). Essa mesma comparação não foi estatisticamente diferente dentro do GEAD. Não houve diferenças estatísticas no TVM e TPS entre os grupos e entre os momentos. Conclusão O programa de exercício domiciliar melhorou a capacidade funcional após 8 semanas de treinamento, mas a percepção de solidão e o teste de velocidade de marcha não foram afetados pelo programa de exercícios físico remoto em idosos isolados devido à pandemia de covid-19.
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