Cancer is an uncontrolled growth of breast cell, it occurs as a result of mutations or abnormal changes, in the genes responsible for regulating the growth of cells and keeping them healthy. The genes are in each cell. Normally, the cell in our bodies replace themselves through an orderly process of cell growth: healthy new cells take over as old ones die out. A tumor can be benign (not dangerous to health) or malignant (has the potential to be dangerous). Benign tumors are not considered cancerous: their cells are close to normal in appearance, they grow slowly, and they do not invade nearby tissues or spread to other parts of the body. Malignant tumors are cancerous. Left unchecked, malignant cells eventually can spread beyond the original tumor to other parts of the body. Breast cancer can be defined as a malignant tumor of breast usually associated with painless lump in the breast usually associated with painless lump in the breast. Available evidence suggests that breast cancer in most parts of Africa is the leading cause of mortality associated with cancers in African women. Recent global cancer statistics indicates rising global incidence of breast cancer with faster increase occurring in developing countries. To determine the histopathologic cell changes in breast cancer using breast disease tissue blocks in Enugu State University Teaching Hospital 2009-2013. Most women with breast cancer seek medical help at the terminal stage of the disease. This may be a contributory factor to increased number of patient having invasive ductal carcinoma (IDC) as seen in the study. The results of this study suggest that breast cancer is increasing in Nigeria and needs an urgent intervention measure. Cancer cells are treatable if only detected early enough, our findings reveals that breast

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