RESUMO: Objetivo: Analisar as notificações de violência por parceiro íntimo (VPI) contra mulheres. Métodos: Estudo transversal com dados de notificação compulsória de VPI contra mulheres (≥ 15 anos de idade) registrados no Sistema de Informação de Agravos de Notificação (Sinan) no período de 2011 a 2017, analisados por meio do teste χ2 e regressão de Poisson com variância robusta para estimar razões de proporção (RP) e respectivos intervalos de confiança de 95% (IC95%). Resultados : Foram notificados 454.984 casos de violência perpetrados por homens contra mulheres, dos quais 62,4% eram VPI. Os tipos de violência mais relatados foram os abusos físicos (86,6%), psicológicos (53,1%) e sexuais (4,8%). VPI esteve associada, positivamente, às mulheres de 20-39 anos de idade (RP = 1,70; IC95% 1,68; 1,71), gestantes (RP = 1,07; IC95% 1,06; 1,08), parceria conjugal (RP = 1,55; IC95% 1,54; 1,56), ocorrência no domicílio (RP = 1,80; IC95% 1,79; 1,81), reincidência da violência (RP = 1,77; IC95% 1,76; 1,78) e ingestão alcoólica pelo agressor (RP = 1,12; IC95% 1,12; 1,13). Violência física associou-se ao grupo de 20-39 aos de idade (RP = 1,03; IC95% 1,02; 1,03). Violência psicológica predominou entre mulheres com ≥ 40 anos de idade (RP = 1,33; IC95% 1,31; 1,35). Violência sexual foi relatada em maior proporção entre gestantes (RP = 2,71; IC95% 2,59; 2,83) e mulheres com deficiência ou transtorno (RP = 2,30; IC95% 2,17; 2,44). Conclusão: A maioria das notificações de violência contra a mulher registradas nos serviços de saúde foi perpetrada por parceiro íntimo, com destaque para a violência física, psicológica e sexual. Foi possível identificar fatores associados à VPI como idade, escolaridade, gestação, ocorrência no domicílio, reincidência e ingestão de bebida alcoólica pelo agressor.

OBJECTIVE: In this study, we intend to identify the prevalence of clinical variables in children with microcephaly.METHODS: This is a cross-sectional and observational study with data collected from medical records of patients admitted to the microcephaly outpatient clinic of a referral center in Teresina-PI. Demographic (gender and age) and clinical data (presence of epilepsy, dysphagia, irritability, and associated comorbidities) were collected. The frequency of Zika virus as a probable etiology was determined from computed tomography patterns and the exclusion of other etiologies by serological tests.RESULTS: A total of 67 patient records were evaluated, of which 31 were male and 36 were female, with a mean age of 1 year and 10 months. The most prevalent clinical variables were epilepsy, present in 47 children (70.2%), and irritability in 37 (55.2%). Also with a high frequency, 22 had dysphagia (32.8%), and 13 had musculoskeletal comorbidities (19.4%). Only three patients in the sample had cardiac abnormalities (4.5%), and no endocrine comorbidity was found. A total of 38 children in the sample (56.7%) presented ZIKV as a probable etiology and, in these cases, there was a higher frequency of epilepsy and dysphagia compared to other etiologies, although not statistically significant.CONCLUSION: Epilepsy, irritability, dysphagia, and musculoskeletal comorbidities were the most frequent clinical variables in children with microcephaly. There was a high prevalence of congenital ZIKV microcephaly syndrome in this sample.

Aim: Both human and rat myometrium express stromal interaction molecule (STIM) and Orai/transient receptor potential canonical (TRPC) proteins, which are components of plasma membrane Ca 2+ store-operated channels. There are reports that these proteins mediate agonist-induced Ca 2+ influx in cultured myometrial cells. In this study, we aimed to determine the effects of Pyr6, an Orai channel blocker, on different agonist-induced contractions in isolated segments of rat uterus. Main findings: In Ca 2+ -free Tyrode's solution, Pyr6 (3 μM) promoted a reduction in both the magnitude and frequency of Ca 2+ (1 mM)-induced uterine contractions after the addition of carbachol (CCh, 100 μM), but not after the addition of oxytocin (OT, 150 nM). In Ca 2+ (0.18 mM)-Tyrode's solution, Pyr6 completely relaxed uterine contractions induced by both CCh and cloprostenol (300 nM), but not those induced by either KCI (40-80 mM) or OT. The addition of Pyr6 abolished the oscillatory uterine contractions induced by Ca 2+ after the addition of cyclopiazonic acid (CPA, 10 μM). When pre-incubated (5 min), Pyr6 reduced the magnitude of both CCh-induced phasic and tonic contractions. The addition of Pyr2 (3 μM), an Orai and TRPC channel blocker, abolished uterine contractions induced by CCh or OT. Conclusion: Considering Pyr6 as an Orai channel blocker and its inhibitory effect on uterine contractions induced by CCh, CPA, and cloprostenol, we suggest that Orai channels are required for the maintenance of contractions induced by these agonists in rat uterus.