Vulvovaginal atrophy is one of the genitourinary symptoms caused by estrogen deficiency which leads to the development of immature vaginal epithelium, glycogen deficiency, reduction or even elimination of lactobacilli, and secondary genitourinary tract infection. Among the main symptoms were dryness, burning, itching, and dyspareunia. Diagnosis is typically based on the patient’s complaints, signs, and symptoms. Management of vulvovaginal atrophy includes various forms of topical estrogens and non-hormonal drugs. Low-dose vaginal estrogens can be used as monotherapy or as a supplement to hormone replacement therapy (HRT). In the case of monotherapy, there is no need to add progesterone for the endometrial protection. According to the recent studies, local vaginal estrogen therapy does not increase the risk of cancer, cardiovascular disease, and venous thromboembolism. On patients with hormonophobia, an alternative method of treatment is the use of vaginal lubricants and moisturizers or who have had cancers of various localization. For instance, usage of lactic acid vaginal gels in breast cancer survivors has improved vaginal dryness and dyspareunia as compared with the placebo. Yet, vaginal estrogen therapy has better clinical effects than non-hormonal drugs.
The main objective of the observational, analytical, one-stage (cross-sectional) study was to determine the prevalence of reproductive disorders depending on who of the grandparents had been exposed to radiation (grandmother, grandfather or both). Methods. On the basis of the results of clinical and paraclinic data, a multistage mathematical analysis was carried out which allowed to trace the influence of radiation factor on the reproductive health of descendants. The main group included 67 women of the second generation of descendants, who were divided into three subgroups according to the criteria of radiation exposure: on grandfather (17 people); on grandmother (28) and on the both (22). The control group included the descendants of people living outside the zone of Semipalatinsk Test Site radiation track (53 women). Results. On the basis of mathematic modelling it was shown, that by maternal inheritance or inheritance from both grandparents, descendants of second generation showed the increase in frequency of menstrual disorders (F = 4.761; р = 0.01), fertility reduction (F = 7.155; р = 0.001), increase of high-risk pregnancy (F = 13.705; р = 0.001), premature birth (F = 5.350; р = 0.01), low birth weight (F = 6.221; р = 0.001). inclusions. Matriliny and patriliny allows one to predict the deterioration of reproductive health in the next (third) generation of offspring.
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