Introduction: Hypohidrotic ectodermal dysplasia (HED) is a congenital disorder affecting the tissues of ectodermal embryonic origin. Hypohidrosis, hypotrichosis, and hypodontia or anodontia represent a clinical triad of the syndrome. The ED individuals have typical facial features, while teeth agenesis in both dentitions, underdeveloped alveolar ridges, and improper maxillo-mandibular relations are the main characteristics of the oro-facial system. Case report: The manifestation of symptoms, way of communication, and the dental management of a patient with Hypohidrotic ectodermal dysplasia were described, following the patient from his 2.5 years until his 8.5 years of age. Removable acrylic dentures -complete denture in the mandible and maxillary teeth-supported overdenture, or mandibular complete denture and maxillary denture fenestrated in the anterior region, at 5.5 and 8.5 years of age respectively, have been produced, while the deciduous teeth have been reshaped using а composite material. Conclusion: When deciding on a dental treatment choice for a HED person, all the factors affecting the final success of the appliances should be considered, of which child's age and skeletal developmental stage are the most important factors. Production of а removable acrylic dentures seems to be the most reasonable, non-invasive and, cost-effective treatment solution in the growing ED patient with severe teeth agenesis.
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